基本説明
神経科学研究で用いられる主要な研究手法や疾患モデルを全３０章に収録。
Covers every major methodology and disease model in the neurosciences from brain injury and stroke to tumours, Parkinson's and epilepsy. Part I Principels and General Methods, Part II. Experimental Models of Major Neurological Diseases.
Full Description
Basic relevant information on methodologies used in neurological disease models can be extremely hard to find. Originally published in 2006, this important reference work contains 30 chapters from over 60 internationally recognized scientists and covers every major methodology and disease model used in neuroscience research. Divided into two major sections, the first deals with general methodologies in neuroscience research covering topics from animal welfare and ethical issues to surgical procedures, post-operative care and behavioral testing. Section two covers every major disease model including traumatic brain injury, ischemia and stroke, to Parkinson's, motor neurone disease, epilepsy and sleep disorders. Delivering critical methodological information and describing small animal models for almost all major neurological diseases, this book forms an essential reference for anyone working in neuroscience, from beginning students to experienced researchers and medical professionals.
Contents
Preface; Part I. Principles and General Methods: 1. Introduction: Animal modelling - a precious tool for developing remedies to neurological diseases Turgut Tatlisumak and Marc Fisher; 2. Ethical issues, welfare laws, and regulations David Whittaker; 3. Housing, feeding, and maintenance of rodents Robert W. Kemp; 4. Identification of individual animals Turgut Tatlisumak and Daniel Strbian; 5. Analgesia, anesthesia, and postoperative care in laboratory animals Naoya Masutomi and Makoto Shibutani; 6. Euthanasia in small animals Turgut Tatlisumak; 7. Various surgical procedures in rodents René Remie; 8. Genetically engineered animals Carolina M. Maier, Lilly Hsieh and Pak H. Chan; 9. Imaging in experimental neurology Marc Fisher, Eng H. Lo and Michael Lev; 10. Safety in animal facilities Tarja Kohila; 11. Behavioural testing in small animal models: ischemic stroke Larry B. Goldstein; 12. Methods for analysing brain tissue Päivi Liesi; 13. Targeting molecular constructs of cellular function and injury through in vitro and in vivo experimental models Zhao Zhong Chong, Faqi Li and Kenneth Maiese; 14. Neuroimmunology and immune-related neuropathologies Bao-Guo Xiao and Hans Link; 15. Animal models of sex differences in non-reproductive brain functions George T. Taylor, Juergen Weiss and Frank Zimmermann; 16. The ependymal route for central nervous system gene therapy Erica Butti, Gianvito Martino and Roberto Furlan; 17. Neural transplantation Stephen B Dunnett, Eduardo M. Torres, Monte A. Gates, and Rosemary A. Fricker-Gates; Part II. Experimental Models of Major Neurological Diseases: 18. Focal brain ischemia models in rodents Fuhai Li and Turgut Tatlisumak; 19. Rodent models of global brain ischemia Julia Kofler and Richard J. Traystman; 20. Rodent models of hemorrhagic stroke Fatima A. Sehba and Joshua B. Bederson; 21. In-vivo models of traumatic brain injury Ronen R Leker and Shlomi Constantini; 22. Experimental models for the study of CNS tumors Taichang Jang and Lawrence Recht; 23. Experimental models for demyelinating diseases Jason M Link, Richard E. Jones, Halina Offner and Arthur A Vandenbark; 24. Animal models of Parkinson's disease Anumantha G. Kathasamy and Siddharth Kaul; 25. Animal models of epilepsy Ricardo M. Arida, Alexandre V. Silva, Margareth R. Priel, and Esper A. Cavalheiro; 26. Experimental models of hydrocephalus Osaama H. Khan and Marc R. Del Bigio; 27. Rodent models of experimental bacterial infections in the CNS Tammy Kielian; 28. Experimental models of motor neuron disease Ruth Danzeisen, Birgit Schwalenstöcker and Albert C Ludolph; 29. Animal models for sleep disorders Seiji Nishino and Nobuhiro Fujiki; 30. Experimental models of muscle diseases Anu Suomalainen, Katja E. Peltola, Anders Paetau and Carina Wallgren-Pettersson.
