遺伝子調節(テキスト)<br>Anatomy of Gene Regulation : A Three-Dimensional Structural Analysis

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遺伝子調節(テキスト)
Anatomy of Gene Regulation : A Three-Dimensional Structural Analysis

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  • 製本 Paperback:紙装版/ペーパーバック版/ページ数 296 p.
  • 言語 ENG
  • 商品コード 9780521804745
  • DDC分類 572.865

基本説明

Graduate Text. The first book to present the parts and processes of gene regulation at the three-dimensional level.

Full Description

No longer simple line drawings on a page, molecular structures can now be viewed in full-figured glory, often in color and even with interactive possibilities. Anatomy of Gene Regulation is the first book to present the parts and processes of gene regulation at the three-dimensional level. Vivid structures of nucleic acids and their companion proteins are revealed in full-color, three-dimensional form. Beginning with a general introduction to three-dimensional structures, the book looks at the organization of the genome, the structure of DNA, DNA replication and transcription, splicing, protein synthesis, and ultimate protein death. Throughout, the text employs a discussion of genetics and structural mechanics. The concise and unique synthesis of information will offer insight into gene regulation, and into the development of methods to interfere with regulation at diseased states. This textbook and its accompanying web site are appropriate for both undergraduate and graduate students in genetics, molecular biology, structural biology, and biochemistry courses.

Table of Contents

Preface                                            xi
A General Introduction to 3-D Structures 1 (5)
The Higher Organization of the Genome 6 (8)
Packing DNA in the Chromosomes 6 (2)
The Three-Dimensional Structure of the 8 (2)
Nucleosome
Other Proteins 10 (4)
Structure of DNA and Telomeres 14 (12)
The Three-Dimensional Structure of DNA 14 (3)
Telomeres 17 (9)
Structure of OnTEBP and Interaction 19 (1)
with Telomeric Sequences
Structure of Yeast RAP1 20 (6)
DNA Replication 26 (47)
The Prereplicative Complex 28 (2)
Replication Origins in Prokaryotes 28 (1)
Replication Origins in Eukaryotes 28 (2)
Elongation and the Synthesis of New DNA 30 (20)
Strands
DNA Polymerases 30 (1)
The Three-Dimensional Structure of DNA 31 (2)
pol I
The Incorporation of the Incoming 33 (3)
Nucleotide
The Three-Dimensional Structure of the 36 (1)
DNA Polymerase from Phage RB69
The Three-Dimensional Structure of 36 (2)
Human DNA Polymerase Beta
Editing 38 (1)
Processivity of DNA Polymerases and the 39 (2)
Structure of the Clamp
The Loading of the Clamp 41 (1)
Processivity Factors of Eukaryotic DNA 42 (1)
Polymerases
Synthesis of the Primers in the Lagging 42 (3)
Strand
Processing of the Okazaki Fragments 45 (3)
into a Continuous Strand
The Single-Stranded DNA-Binding Proteins 48 (1)
Viewing the Replication Complex 48 (2)
Helicases 50 (8)
The E. coli Rep Helicase 51 (2)
The Bacillus stearothermophilus PcrA 53 (1)
Helicase
The Bacteriophage T7 Helicase Domain 53 (5)
Topoisomerases 58 (9)
The 3-D Structure of Human Topo I 61 (1)
Mechanism of Cleavage and Relaxation of 61 (4)
DNA
The Structure of Yeast Topoisomerase II 65 (2)
Termination of Replication 67 (4)
Box: How Drugs Induce Mutations 71 (2)
Transcription in Prokaryotes 73 (31)
Structure and Function of Prokaryotic RNA 74 (3)
Polymerase
The 3-D Structure of the Thermus 77 (9)
Aquaticus RNA Pol
Regulation in Prokaryotes 86 (4)
The Helix-Turn-Helix Motif in 87 (1)
Prokaryotic Gene Regulation
The Lac Operon 87 (2)
The Pur Repressor 89 (1)
The Trp Repressor 89 (1)
Catabolite Activator Protein 90 (1)
Regulation in Phages 90 (8)
The 434 Phage 92 (3)
The Lambda Phage 95 (3)
Termination of Prokaryotic Transcription 98 (6)
The Attenuator 101(3)
Transcription in Eukaryotes 104(49)
Structure and Function of the Yeast RNA 105(3)
Pol II
Comparison of Prokaryotic and Eukaryotic 108(3)
RNA Polymerases with the T7 RNA Polymerase
Regulation in Eukaryotes 111(9)
Regulation in Class I Genes 111(1)
Regulation in Class III Genes 111(2)
Structure of TFIIIA 113(2)
Regulation in Class II Genes 115(1)
The Basal Transcriptional Apparatus in 115(1)
Class II Genes
Structure and Function of TFIID 116(2)
Structure of TFIIA 118(1)
Structure of TFIIB 119(1)
Structure of TFIIH 120(1)
Transcriptional Activation in Eukaryotes 120(8)
Liver-Specific Transcription 121(1)
The GAL Regulatory System 122(1)
The Steroid Hormone Receptors 123(1)
The Homeodomain-Containing Genes 124(3)
The Mediator 127(1)
Chromatin Structure and Gene Regulation 128(2)
Regulation of Cell Fate by Homeodomains: 130(2)
The Yeast Mat Genes
Structural Features of Class II 132(20)
DNA-Binding Domains
The Helix-Turn-Helix Motif 133(2)
The Zinc-Binding Domains 135(1)
The Class 1 Zinc-Binding Domains 136(4)
The Class 2 Zinc-Binding Domains 140(2)
The Class 3 Zinc-Binding Domains 142(1)
Other DNA-Binding Domains 143(1)
The Leucine Zipper 144(1)
The Immunoglobulin Fold in NFAT 145(3)
The T Domain 148(1)
Signal Transducers and Activators of 148(4)
Transcription Proteins
Box: Most Frequent Base-Amino Acid 152(1)
Interactions
Splicing 153(19)
Splicing of the Nuclear Pre-mRNA Introns 155(5)
The First Transesterification 155(1)
The Second Transesterification 155(1)
The Spliceosome 156(1)
Structure and Assembly of snRNPs 156(1)
Other Splicing Factors 157(2)
The Events of Splicing 159(1)
Splicing of Group II Introns 160(3)
Splicing of Group I Introns 163(4)
Other Ribozymes 167(5)
Structure of the Hammerhead Ribozyme 167(3)
The Interesting Case of Group I 170(2)
Splicing by a Protein, Tyrosyl-tRNA
Synthetase
Modifications of mRNA 172(12)
The Capping of the 5' Ends 172(6)
Structure of the Yeast RNA 173(1)
5'-Triphosphatase
Structure of the Guanyltransferase 173(5)
Maturation at The 3' End: Addition of 178(3)
polyA
3-D Structure of the polyA-Binding 179(1)
Protein
Maturation of mRNA Lacking polyA Tails 180(1)
RNA Editing 181(1)
RNA Interference 182(2)
Compartmentalization of Transcription 184(7)
Splicing Factors 185(1)
Visualization of Single Transcripts 185(2)
The Moving of Transcripts Out of the 187(3)
Nucleus
Shuttling mRNA-Binding Proteins 190(1)
Segregation of Replication and 190(1)
Transcription
Protein Synthesis 191(50)
The Major Players in Protein Synthesis 193(9)
The 3-D Structure of tRNA 193(1)
The Charging of tRNA with Amino Acid 194(1)
The 3-D Structure of E. coli 195(5)
Glutaminyl-tRNA Synthetase and Its
Interactions with tRNAGln
The Ribosome 200(2)
Initiation 202(8)
Initiation in Prokaryotes 203(1)
Initiation in Eukaryotes 203(2)
The Structure of IF-1 205(1)
The Structure of IF-3 205(2)
The Structure of IF-2/eIF-5B 207(1)
The Structure of eIF-4E and eIF-4G 207(2)
The Structure of eIF-1 and eIF-1A 209(1)
Elongation 210(9)
The Structure of Elongation Factors 212(2)
EF-Tu and EF-G
Movement of tRNAs During Translocation 214(3)
Movement of EF-G and Conformational 217(2)
Changes of the Ribosome During
Translocation
Interactions Between the 30S and 50S 219(13)
Subunits
Interactions Between tRNA and rRNAs 221(1)
Interactions Between tRNA and 16S rRNA 222(1)
Interactions Between tRNA and 23S rRNA 223(7)
Interactions Between tRNA and 5S rRNA 230(2)
The Decoding Center of the Ribosome 232(4)
The Peptide Bond Center 236(1)
Termination of Protein Synthesis 237(2)
The Three-Dimensional Structure of 237(1)
Human eRF1
Mechanism of Stop Codon Recognition 238(1)
The Ribosome Recycling Factor 239(1)
Box: How Do Antibiotics Work? A Lesson 239(2)
from the 3-D Structure of the Ribosome
The Birth and Death of Proteins 241(18)
The Signal Peptide and Its Recognition 242(1)
Structure and Function of the Signal 243(4)
Recognition Particle
The Barrel of Birth . . . 247(8)
The 3-D Structure of DnaK and Hsp70 249(2)
The 3-D Structure of DnaJ 251(1)
The 3-D Structure of GrpE 251(1)
The 3-D Structure of Prefoldin 252(1)
The 3-D Structure of GroEL and GroEs 252(3)
. . . And The Barrel of Death 255(4)
Further Reading and References 259(12)
Index 271