Full Description
This reference work evaluates the cellular and molecular basis of cancer as a disease of abnormal cell proliferation and discusses novel oncogenes included among the most interesting elements in the pathogenesis of human malignancy. The book examines the expanding role of secreted growth factor activities in malignant progression, featuring a report on fibroblast growth factors, a related family of growth factors that represent products of specific oncogenes. The volume reveals specific evidence for the participation of growth factors in autocrine and paracrine loops that contribute to tumor pathogenesis. It also presents systemic analyses of breast and lung cancers that underscore the complicated control of growth regulation for both normal and malignant cells.
Contents
int-2: A Gene Implicated in Normal Fetal Development and Virally Induced Tumorigenesis (C. Dickson, et al.); Function of Differential myc-Family Gene Expression: Transgenic and Homologous Recombination Models (A. Ma, et al.); Analysis of the Lymphocyte-Specific Tyrosine Protein Kinase p56lck in T Cells (A. Veillette, et al.); Fibroblast Growth Factor and Its Role in Development (D. Gospodarowicz); Post Translational Processing of Human Pro-Gastrin Releasing Peptide in Small Cell Lung Carcinoma Cell Lines (A.-M; Lebacq-Verheyden, et al.); Isolation and Characterization of DNA-Binding Factors Regulating Transcription of the EGF Receptor Proto-Oncogene (G. Merlino, et al.); Ligand-Induced Downregulation of Glucocorticoid Receptors Is Enhanced by the Expression of Oncogenes (W. Hoeck, et al.); Models for Studying the Progression From Hormone-Dependent to Hormone-Independent Growth in Human Breast Cancer (N. Br; nner, et al.); Regulation of Normal and Malignant Breast Epithelial Proliferation (M. Lippman & R. Dickson); Abstracts; Index.
