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基本説明
A Unique Collection of High-Quality Articles – Derived from the Acclaimed Encyclopedia of Life Sciences. The aim of the Handbook is to bring together under the same cover the many and varied strands of our knowledge of human/primate/vertebrate molecular evolution. Hence, the 282 chapters that comprise this essential reference work have been thematically arranged into twelve sections, covering the whole scope of research into human molecular evolution: General Concepts in Evolutionary Genetics; Mutation, Adaptation and Natural Selection; Evolutionary and Population Genetics; Human Evolution; Human Genome Evolution; Evolution of Human Gene Structure and Function; Evolution of Gene Expression; and more.
Full Description
"This splendid compendium ... will be the standard reference work for years to come: a handbook to browse, to consult, to look things up in, and to read with pleasure, wonder and post-Darwinian exhilaration."
—Richard Dawkins
"This is a marvellous book... It should be in every university library - preferably in several copies - and every reader of this journal should add it to their next grant application. It really is that good.... I have already found this book to be invaluable.... For many years to come, these two volumes will be the starting point for anyone wishing to find out about virtually any subject relating to human genetics.... Any scientist working on humans or other animals will find many things in these pages that will stimulate, inform and inspire. The authors, editors and publishers are to be congratulated for their work... order a copy now!"
—HUMAN GENETICS
"The publishers and editors deserve to be congratulated for publishing this major book which coincides with the 200th anniversary of the birth of Charles Darwin. The book is well-timed, with biologists, theologians and sociologists engaged in intense debate on the Darwinian Theory on the origin of species, evolution and natural selection... There is little doubt that this marvellous publication should be in the library of universities and academic institutions dealing with basic and applied biology research and education.... It will not be surprising if the individual academic or researcher decides to invest in this resource and enrich their personal collection of leading books in genetics and genomics."
—GENOMIC MEDICINE
A Unique Collection of High-Quality Articles - Derived from the Acclaimed Encyclopedia of Life Sciences
The revolution in human molecular genetics which has taken place over the last three decades has yielded a wealth of information not only on the structure and function of our genes, but also on gene expression, mutation and polymorphic variation. Over the last five years, the focus has moved from genes to genomes. Even though the annotation of our ‾30,000 genes is still in progress, genome-wide studies have already yielded abundant evidence for the signatures of past selection and adaptive evolution within human gene sequences. Further, the completion of the sequencing of the 3 billion base-pair human genome, coupled with the increasing availability of other vertebrate genome sequences, has ushered in a new era of comparative genomics. We are now able to identify many of the molecular events (from the chromosomal level down to the single base-pair) that have occurred during vertebrate, mammalian, primate and hominid evolution. Indeed, the detailed comparison of the human and chimpanzee genomes has begun to reveal some of the genetic changes that have been involved in the development of human lineage-specific traits. We are thus acquiring the ability to ask searching questions about our origins, about the demographic processes associated with the global radiation of humankind, as well as some of the unique adaptations that make us human.
Evolutionary biology has become so broad that its impact may be felt across the spectrum of the biological sciences. The aim of the Handbook of Human Molecular Evolution is relatively straightforward: to bring together under the same cover the many and varied strands of our knowledge of human/primate/vertebrate molecular evolution. Hence, the 282 chapters that comprise this essential reference work have been thematically arranged into twelve sections, covering the whole scope of research into human molecular evolution:
General Concepts in Evolutionary Genetics
Mutation, Adaptation and Natural Selection
Evolutionary and Population Genetics
Human Evolution
Human Genome Evolution
Evolution of Human Gene Structure and Function
Evolution of Gene Expression
Mitochondrial Genome Evolution
Chromosomal Evolution
Comparative Genomics
Evolution and Disease Susceptibility
Analysis of Ancient DNA
This conceptual outline informed the selection of the chapters themselves and the connections between them. Some of these chapters are intended to be introductory, aimed at undergraduates and non-specialists. They provide basic information and a list of recommended further reading to encourage the reader to explore a topic in more depth. This approach helps the student reader progress from textbook material to primary literature. Some chapters are overviews that address topics of broad interest and importance, while others focus on quite specialized topics. These chapters are written for postgraduate students and research workers; they contain more detailed information and key references allowing the reader to investigate a specific area in more depth. This format allows professionals to use the books as a quick reference source. The chapters are richly supplied with website information to allow access to relevant data sources over the internet. The self-contained, peer-reviewed articles in this unique handbook have been written by leading scientists in each field.
Key topics include the evolution of enzyme function, the use of nucleic acid divergence as a "molecular clock", the origin of non-functional or junk DNA, the role of gene duplication in the emergence of novel gene function and the identification of molecular changes responsible for various human characteristics especially those pertaining to infection, cognition, disease and disease susceptibility.
The Handbook of Human Molecular Evolution has adopted an integrated approach to the study of human evolution and seeks throughout to emphasize the interplay between molecular genetic concepts and principles on the one hand, and information acquisition and interpretation on the other. In this way, it is hoped that the 'documents of evolutionary history' written into the fabric of our genome, will become accessible to the widest possible audience.
Contents
General Concepts in Evolutionary Genetics
Views of Evolution
James F Crow
Evolution: Selectionist View
Andreas Wagner
Evolution: Neutralist View
Andreas Wagner
The Neo-selectionist Theory of Genome Evolution
Giorgio Bernardi
Fitness and Selection
Brian Charlesworth
Genetic Drift in Human Populations
Andrew J Bohonak
Heterozygosity
Wen-Hsiung Li
Effective Population Size
Michael C Whitlock
Population Differentiation: Measures
Stefano Mona, Giorgio Bertorelle
Evolutionary Distance
Wen-Hsiung Li
Gene Trees and Species Trees
Wen-Hsiung Li
Homologous, Orthologous and Paralogous Genes
Wen-Hsiung Li
Evolution: Convergent and Parallel Evolution
Caro-Beth Stewart
Mutation, Adaptation and Natural Selection
Genetic Variation: Polymorphisms and Mutations
Alan F Wright
Polymorphisms: Origins and Maintenance
Kenneth M Weiss
Molecular Evolution: Introduction
David Penny
Molecular Evolution: Overview
Jan Klein
Molecular Evolution: Genetics of Adaptation
Michael Travisano
Neutral Theory of Molecular Evolution
Naoyuki Takahata
Molecular Evolution: Nearly Neutral Theory
Tomoko Ohta
Molecular Evolution: Rates
Lindell Bromham
Molecular Evolution: Patterns and Rates
Lindell Bromham
Nucleotide Substitution: Rate of
Wen-Hsiung Li
Synonymous and Nonsynonymous Rates
Soojin Yi
Mutational Change in Evolution
Dan Graur
Mutations and New Variation: Overview
Mark O Johnston
Single-base Mutation
Dan Graur
Mutation Rate
Bertram Müller-Myhsok
Mutation Rates: Evolution
David Metzgar
Spectrum of Mutations in the Human Genome Inferred by Single Nucleotide Polymorphisms
Zhao Zhongming
Mutational Biases
Lev Y Yampolsky, Arlin Stoltzfus
Mutations: Dating
Roberto Colombo
Diffusion Theory
Gil McVean
Molecular Clocks in Mammals
Wen-Hsiung Li, Kateryna D Makova
Molecular Clocks
Andrew Peter Martin
Purifying Selection: Action on Silent Sites
R Nielsen, H Akashi
Selection against Amino Acid Replacements in Human Proteins
Sankar Subramanian
Identifying Regions of the Human Genome that Exhibit Evidence for Positive Selection
Ryosuke Kimura, Jun Ohashi
Positive Selection on Genes in Humans as Compared to Chimpanzees
Margaret A Bakewell, Jianzhi Zhang
Selection Operating on Protein-coding Genes in the Human Genome
Diogo Meyer, Eugene E Harris
Selective and Structural Constraints
Austin L Hughes
Substitution Matrices
Stephen F Altschul
Fixation Probabilities and Times
Sarah P Otto, Michael C Whitlock
Genetic Code: Evolution
Edward N Trifonov
Codon Usage in Molecular Evolution
Richard L Grantham
Linkage Disequilibrium
Peter JP Croucher
Recombination and Human Genetic Diversity
Chris CA Spencer
Comparison of Rates and Patterns of Meiotic Recombination between Human and Chimpanzees
Jan Freudenberg
Rapid Evolution of Genes on the Human X-chromosome
Erika M Kvikstad, Kateryna D Makova
Evolutionary and Population Genetics
Gene Flow, Haplotype Patterns and Modern Human Origins
Alan R Templeton
HapMap Project
Bryan J Traynor, Andrew Singleton
Migration
Guido Barbujani
Nonrandom Mating
Dennis H O'Neil
Human Population Stratification and its Assessment by Microarray Genotyping
Marc Bauchet
Sequence Alignment
Julie D Thompson, Olivier Poch
Sequence Similarity
Jaap Heringa
Phylogenetics
Wen-Hsiung Li
Phylogenetic Footprinting
Wyeth W Wasserman, Wynand Alkema
Molecular Phylogeny Reconstruction
Sudhir Kumar, Alan Filipski
Evolutionary Distance: Estimation
Masatoshi Nei, Jianzhi Zhang
Coalescent Theory
Simon Tavaré
Stationary Allele Frequency Distributions
Bruce Rannala
Developmental Evolution
Susan Lindsay
Morphological Diversity: Evolution
Graham Budd
Male-driven Evolution
Hans Ellegren
Coevolution: Molecular
Ronald M Adkins
Concerted Evolution
Daiqing Liao
Sociobiology, Evolutionary Psychology and Genetics
Patrick Bateson
Are Humans Still Evolving?
Floyd A Reed
Human Evolution
Hominids: Molecular Phylogenetics
Ulfur Arnason, Morgan Kullberg
Human Evolution: Overview
Bernard A Wood
Molecular Clocks: Determining the Age of the Human--Chimpanzee Divergence
Michael I Jensen-Seaman, Kathryn A Hooper-Boyd
On the Number of Ancestral Human Species
Darren Curnoe
Human Evolution: Early Radiations
Bernard A Wood
Human Evolution: Radiations in the Last 300000 Years
Osbjorn M Pearson
Modern Humans: Origin and Evolution
Todd R Disotell
Modern Human Origins: The `Out of Africa' Debate
John H Relethford
Origin of Modern Humans: Interpreting the Molecular Evidence
Henry C Harpending
Human Populations: Evolution
Rebecca L Cann
Human Populations: Origins and Evolution
Rosalind M Harding, John H Relethford
Humans: Demographic History
Henry Harpending
DNA Markers and Human Evolution
Rebecca L Cann
Reconstructing Human History Using Autosomal, Y-Chromosomal and Mitochondrial Markers
Bryndis Yngvadottir, Denise R Carvalho-Silva
Population History and Linkage Disequilibrium
Sebastian Zollner
Human Population Genetics: Drift and Migration
Ranajit Chakraborty
Human Genetics and Languages
David Comas, Elena Bosch, Francesc Calafell
Surnames and Genetics
Mark A Jobling
Population History of Europe: Genetics
Guido Barbujani
Genetic Diversity in Africa
Alicia Sanchez-Mazas, Estella S. Poloni
Genetic Diversity in the German Population
Michael Krawczak, Timothy T Lu, Sascha Willuweit, Lutz Roewer
Genetics and the History of the Basque People
Santos Alonso
Genetics and the Origins of the British Population
Martin Richards, Cristian Capelli, James F Wilson
Genetics and the Origins of the Chinese
Qing-Peng Kong, Hui Pan, Ya-Ping Zhang
Genetics and the Origins of the Finns
Reijo Norio
Genetics and the Origins of the Irish
Brian McEvoy, Daniel G Bradley
Genetics and the Origins of the Polynesians
Geoffrey K Chambers
Origins of the Australian and New Guinean Aborigines
Sheila M van Holst Pellekaan
Origins of the Austro-Asiatic Populations
B Mohan Reddy, Vikrant Kumar
Peopling of India: Insights from Genetics
Partha P Majumder
Population Genetics of the Ashkenazim
Marina Faerman
Roma (Gypsies): Genetic Studies
Bharti Morar, Luba Kalaydjieva
The Peopling of the Americas as Revealed by Molecular Genetic Studies
Theodore G Schurr
Primates and the Origin of Culture
WC McGrew
Human Genome Evolution
Evolution of Genome Organization
Wolfgang Stephan
Genome Organization of Vertebrates
Giorgio Bernardi
Evolutionary History of the Human Genome
Giorgio Bernardi
Sequencing the Human Genome: Novel Insights into its Structure and Function
Hildegard Kehrer-Sawatzki, David N Cooper
Single Nucleotide Polymorphism (SNP)
Anthony J Brookes
Human Genetic Diversity
Lynn B Jorde
Human and Chimpanzee Nucleotide Diversity
Henrik Kaessmann
Divergence between the Human and Chimpanzee Genomes and its Impact on Protein and Transcriptome Evolution
Hildegard Kehrer-Sawatzki, David N Cooper
Indels in the Evolution of the Human and Chimpanzee Genomes
Anna Wetterbom, Lucia Cavelier, Tomas F Bergström
Inferring the Process of Human--Chimpanzee Speciation
K Ryo Takahasi, Hideki Innan
Human Genome Diversity Project (HGDP)
Morris W Foster
Blocks of Limited Haplotype Diversity
Newton E Morton
Gene Conversion during Primate Evolution
Yoko Satta
Biased Gene Conversion and its Impact on Human Genome Evolution
Nicolas Galtier, Laurent Duret
Repetitive DNA: Evolution
Wolfgang Stephan, J Bruce Walsh
Simple Sequence Repeats in the Human Genome: Evolution
Donald E Riley, John N Krieger
Evolution of Microsatellite DNA
Iris M Vargas Jentzsch, Andrew Bagshaw, Emmanuel Buschiazzo, Angelika Merkel, Neil J Gemmell
Evolution of Alpha Satellite DNA
Duroica Ugarkovic
Comparative Genetics of Trinucleotide Repeats in the Human and Ape Genomes
Loris Mularoni, Macarena Toll-Riera, M Mar Albà
Endogenous Retroviral Sequences; their Evolutionary Contribution to the Human Genome
Jens Mayer
Human Endogenous Retroviruses; Evolutionary Dynamics, Chromosomal Location and Host Benefit
Paul Nelson, Graham Freimanis, Denise Roden
Evolutionary History and Impact of Human DNA Transposons
Cédric Feschotte
Evolution of Human Retrosequences: Alu
Astrid M Roy-Engel, Mark A Batzer, Prescott L Deininger
Long Interspersed Nuclear Elements (LINEs): Evolution
Anthony V Furano, Stéphane Boissinot
Bacterial DNA in the Human Genome
Jan O Andersson
Chromosome-specific Repeats (Low-copy Repeats)
M-C Potier, G Golfier, EE Eichler
Telomere
Christa Lese Martin, David H Ledbetter
Telomeric and Subtelomeric Repeat Sequences
Dmitri Churikov, Carolyn M Price
Subtelomeres: Evolution in the Human Genome
M Katharine Rudd
The Evolution of Centromeric DNA Sequences
Joshua J Bayes, Harmit S Malik
Segmental Duplications and Their Role in the Evolution of the Human Genome
Yali Xue, Chris Tyler-Smith
Copy Number Variation in the Human Genome
Hildegard Kehrer-Sawatzki
Gene Duplication: Evolution
Wen-Hsiung Li
Gene Families: Formation and Evolution
Tomoko Ohta
Gene Families: Multigene Families and Superfamilies
Tomoko Ohta
Gene Clustering in Eukaryotes
Jeffrey G Lawrence, Thomas Blumenthal
Clustering of Highly Expressed Genes in the Human Genome
Hinco J Gierman, Rogier Versteeg
Gene Distribution in Human Chromosomes
Giorgio Bernardi, Salvatore Saccone
Evolution of Gene Deserts in the Human Genome
James Taylor
The Impact of Gene Duplication on Human Genome Evolution
James A Cotton
Genetic Redundancy
David C Krakauer
DNA Methylation: Evolution
Aharon Razin, Ruth Shemer
Evolution of Imprinting: Imprinted Gene Function in Human Disease
Benjamin JA Dickins, Gavin Kelsey
Imprinting: Evolution
Hamish G Spencer
Epigenetic Variation in Humans
Jon F Wilkins
Dosage Compensation Mechanisms: Evolution
Ignacio Marín
Evolution of X-chromosome Inactivation
Alexander I Shevchenko, Suren M Zakian
Ultraconserved DNA Sequence Elements in the Human Genome
Alison P Lee, B Venkatesh
The Biological Significance of Conserved Non-Generic DNA
Emmanouil T Dermitzakis
Evolutionarily Conserved Noncoding DNA
Anil G Jegga, Bruce J Aronow
Human-specific Accelerated Evolution of Noncoding Sequences
Matthew T Webster
Rapidly Evolving Regions of the Human Genome
Subhash Mohan Agarwal
GC-Rich Isochores in the Interphase Nucleus
Salvatore Saccone, Giorgio Bernardi
Evolution of Human Gene Structure and Function
Gene Structure: Evolution
Tomoko Ohta
Gene Evolution and Human Adaptation
Eugene E Harris
The Evolution of Introns in Human Genes
Elodie Gazave, Olga Fernando, Arcadi Navarro
Intron Evolution in Duplicated Human Genes
Kamel Jabbari, Edda Rayko
Intron Loss and Gain
Tobias Mourier, Daniel C Jeffares
Introns: Movements
Manyuan Long, Rüdiger Cerff
Introns: Phase Compatibility
László Patthy
Evolutionarily Conserved Intronic Splicing Regulatory Elements in the Human Genome
Eric L Van Nostrand, Gene W Yeo
Evolutionary Conservation of Splice Sites
Michelle L. Hastings, Ravi Sachidanandam
Alternative Splicing: Evolution
László Patthy
Alternative Splicing in the Human Genome and its Evolutionary Consequences
Liliana Florea
Dual-coding Regions in Alternatively Spliced Human Genes
Han Liang, Laura F Landweber
Birth and Evolution of Human Exons
Maria Dulcetti Vibranovski, Noboru Jo Sakabe, Manyuan Long
Exons and Protein Modules
László Patthy
Insertion and Deletion of Exons During Human Gene Evolution
David N Cooper
Exons: Shuffling
László Patthy
Pseudoexons
Manyuan Long
Domain Duplication and Gene Elongation
Wen-Hsiung Li
Kateryna D Makova
The Contribution of Frameshift Translation to the Generation of Novel Human Proteins
Kohji Okamura, Stephen W Scherer
Transposable Element-driven Duplications during Hominoid Genome Evolution
Bud Mishra
The Contribution of Transposable Elements to Human Proteins
Jean-Nicolas Volff
Evolutionary Emergence of Genes Through Retrotransposition
Richard Cordaux, Mark A Batzer
Multigene Families: Evolution
J Bruce Walsh, Wolfgang Stephan
Paralogous Genes and Chromosomal Regions
Lars-Gustav Lundin, Dan Larhammar, Finn Hallböök
Bi-directional Gene Pairs in the Human Genome
Kanako O Koyanagi, Tadashi Imanishi, Takashi Gojobori
Gene Fusion
Esther Betrán
Protein Families: Evolution
Richard R Copley
Fibroblast Growth Factors: Evolution
David M Ornitz
Globin Genes: Evolution
Ross C Hardison
Hox Genes and Body Plan: Evolution
Ella Tour, William McGinnis
Pax Genes: Evolution and Function
Maxime Bouchard, Alexander Schleiffer, Frank Eisenhaber, Meinrad Busslinger
Low-density Lipoprotein Receptor (LDLR) Family: Genetics and Evolution
Wolfgang Johann Schneider
Major Histocompatibility Complex (MHC) Genes: Evolution
Austin L Hughes
Major Histocompatibility Complex (MHC) Genes: Polymorphism
Diogo Meyer
Steven J Mack
Vertebrate Immune System: Evolution
Austin L Hughes
Evolution of the Human Immune System
Nadia Danilova
Complement System: Evolution
Masaru Nonaka
Somatic Hypermutation of Antigen Receptor Genes: Evolution
Marilyn Diaz, Laurent K Verkoczy
Neuropeptides and their Receptors: Evolution
Charles HV Hoyle
Nuclear Receptor Genes: Evolution
Gareth I Owen
Olfactory Receptor Genes: Evolution
Yoshihito Niimura
Visual Pigment Genes: Evolution
Shozo Yokoyama
Bitter Taste Sensitivity in Humans and Chimpanzees
Maik Behrens, Wolfgang Meyerhof
Evolution of Skin Pigmentation Differences in Humans
Heather Norton
Population Genetics of Lactase Persistence and Lactose Intolerance
Catherine Janet Ellen Ingram, Dallas Mary Swallow
Defensins: Evolution
Austin L Hughes
Cystic Fibrosis Transmembrane Conductance Regulator Sequences: Comparative Analysis
Jian-Min Chen, Guillaume Lecointre, Erick Denamur, Claude Férec
ATP-binding Cassette (ABC) Transporter Supergene Family: Genetics and Evolution
Michael Dean
Proteases: Evolution
Christopher Southan
Serpins: Evolution
Gary A Silverman, David J Askew, James A Irving, Cliff J Luke, Dion Kaiserman, Phillip I Bird, James C Whisstock
Adaptive Evolution of Primate Sperm Proteins
Nathaniel L Clark
Drug Metabolism: Evolution
Daniel W Nebert
rRNA Genes: Evolution
Iris L Gonzalez, James E Sylvester
MicroRNA Evolution in the Human Genome
Bing Su, Rui Zhang
Pseudogene Evolution in the Human Genome
Zhaolei Zhang, Deyou Zheng
Human Lineage-specific Gene Inactivation
Wendy E Grus, Jianzhi Zhang
Pseudogenes: Age
Allen R Rhoads, Felix Friedberg
Pseudogenes: Patterns of Mutation
Rosa Martínez-Arias, Francesc Calafell, Jaume Bertranpetit
Processed Pseudogenes and Their Functional Resurrection in the Human and Mouse Genomes
Hiroaki Sakai, Takeshi Itoh, Takashi Gojobori
Evolution of Gene Expression
Transcriptional Regulation: Evolution
Gregory A Wray
Promoters: Evolution
Deborah L Gumucio
Evolution of Human Gene Expression Control
Courtney C Babbitt, Gregory A Wray
Positive Selection and the Evolution of Prodynorphin
Matthew V Rockman
Human Transcriptome Evolution
Xun Gu, Yong Huang
Evolution of Gene Expression in Human and Chimpanzee Brains
Naoki Osada, Sugano Sumio, Yutaka Suzuki
Human and Chimpanzee Transcriptomes: Comparative Evolution
Philipp Khaitovich, David Cooper, Hildegard Kehrer-Sawatzki
Human and Macaque Transcriptiomes: A comparison
Stephen J Walker
Transcription Factor-binding Sites: Recent Evolution in the Human Lineage
Berthold Göttgens
Alternative Polyadenylation in the Human Genome: Evolution
Bin Tian
Mitochondrial Genome Evolution
Mitochondrial Genome: Evolution
Mark Stoneking
Mitochondrial Non-Mendelian Inheritance: Evolutionary Origin and Consequences
C William Birky Jr
Mitochondrial Genome Sequences and Their Phylogeographic Interpretation
Vincent Macaulay, Martin Richards
Mitochondrial Origins of Human Nuclear Genes and DNA Sequences
William F Martin
Chromosomal Evolution
Chromosomes in Mammals: Diversity and Evolution
Johannes Wienberg, Stefan Müller
Chromosome Numbers in Mammals
Harry Scherthan
Chromosome Rearrangement Patterns in Mammalian Evolution
Johannes Wienberg, Stefan Müller
Hotspots of Mammalian Chromosome Evolution
Lutz Froenicke, Leslie A Lyons
Chromosomal Rearrangements in Primates
Roscoe Stanyon, Francesca Bigoni
Chromosomal Rearrangements in the Human and Chimpanzee Lineages
Hildegard Kehrer-Sawatzki, David N Cooper
Human Chromosome Evolution
Gerald P Holmquist, Johannes Wienberg
Polyploid Origin of the Human Genome
Masanori Kasahara
Chromatin Structure and Human Genome Evolution
Colin AM Semple
Mammalian Sex Chromosome Evolution
Gerald J Wyckoff, Christine M Malcom
Evolution of the Mammalian X Chromosome
Paul D Waters, Terence J Robinson
Y Chromosome Evolution
Vladimir A Gvozdev
X and Y Chromosomes: Homologous Regions
Nisrine El-Moghabel, Jennifer A M Graves
Evolution of Common Fragile Sites
Anne Helmrich
Comparative Genomics
Comparative Cytogenetics
Matthew Breen, Cordelia Langford
Comparative Cytogenetics Technologies
Stefan Müller, Johannes Wienberg
Reconstruction of Ancestral Genomes
Roscoe Stanyon, Fiorella Garofalo, Francesca Bigoni
Comparative Human Genomics
I King Jordan, Eugene V Koonin
Orthologues, Paralogues and Xenologues in Human and Other Genomes
Olga Zhaxybayeva, J Peter Gogarten, Lorraine Olendzenski
Comparing the Human and Sea Urchin Genomes
R Andrew Cameron
Comparing the Human and Fish Genomes
Yoichiro Nakatani, Shinichi Morishita
Comparing the Human and Medaka Genomes
Takashi Sasaki, Nobuyoshi Shimizu
Fugu: The Pufferfish Model Genome
B Venkatesh
The Mouse Genome as a Rodent Model in Evolutionary Studies
Jessica Vamathevan, Joanna D Holbrook, Richard D Emes
The Rat Genome as a Rodent Model in Evolutionary Studies
Kim Fechtel
Comparing the Human and Canine Genomes
Marek Switonski, Izabela Szczerbal
Primate Phylogenetics
Todd R Disotell
The Sequencing of the Rhesus Macaque Genome and its Comparison with the Genome Sequences of Human and Chimpanzee
Richard A Gibbs, Kim C Worley, Hildegard Kehrer-Sawatzki, David N Cooper
The Chimpanzee Genome Project
David N Cooper, Hildegard Kehrer-Sawatzki
Comparing the Human and Chimpanzee Genomes
Monica Uddin, Derek E Wildman, Morris Goodman
Nucleotide Sequence Divergence between Humans and Chimpanzees
Feng-Chi Chen, Trees-Juen Chuang
Human-specific Changes of Genome Structure
R Alan Harris, Aleksandar Milosavljevic
Evolution and Disease Susceptibility
Evolutionary Thinking in the Medical Sciences
Stephen C Stearns
Darwinian Medicine
George C Williams
Pathological Missense Mutations Provide New Insights into the Evolution of Trypsinogen Genes
Jian-Min Chen, David N Cooper, Claude Férec
Balancing Selection in Human Evolution
Eric J Vallender, Welkin E Johnson
Selective Constraints on Human Disease Mutations and Polymorphisms
Hernán Dopazo
Genetic of Large Populations and Association Studies
Pauline Hélène Garnier-Géré, Lounès Chikhi
Genetic Disease in the Ashkenazim: Role of a Founder Effect
Inbal Kedar-Barnes, Paul Rozen, Mordechai Shohat
Hagit N Baris
Single Nucleotide Polymorphisms in Human Disease and Evolution: Phylogenies and Genealogies
Paul D Thomas
Structural Diversity of the Human Genome and Disease Susceptibility
Richard S Smith, María Gutiérrez-Arcelus, Charles W Tran, Stephanie Park, Cheryn J Couter, Charles Lee
Segmental Duplications and Genetic Disease
Beverly S Emanuel, Tamim H Shaikh
Genetics of Susceptibility to Human Infectious Diseases
Richard A Kaslow, Sadeep Shrestha, Jianming 'James' Tang
The Genetics of Malarial Resistance and Susceptibility
Brian C Verrelli
The Evolution of Fatness and Susceptibility to Obesity
Jonathan CK Wells
Thrifty Genotype Hyphothesis and Complex Genetic Disease
Pnina Varidi, Konstantin Bloch
An Evolutionary Framework for Common Disease
Francesca Luca, Anna Di Rienzo
On Sequence Variants that Influence the Risk of Common Diseases
Kári Stefánsson, Jeffrey R Gulcher
An Evolutionary Genetic Framework for Heritable Disorders
Matthew C Keller
Analysis of Ancient DNA
Ancient DNA: Recovery and Analysis
Susanne Hummel
Ancient DNA: Phylogenetic Applications
Michael Knapp, Linda Vigilant, Michael Hofreiter
Neanderthal Mitochondrial DNA
William Goodwin, Igor Ovchinnikov
Reconstructing Ancient DNA Sequences in Silico
Jian Ma
