基本説明
Details the biological and biochemical bases of galectins in various pathologies and drug design.
Full Description
The comprehensive guide to the current understanding of galectins and their promising potential in drug design
This is the first book focusing on galectins. It was inspired by topics discussed at the symposium "Galectins: Structures, Functions, and Therapeutic Targets" that was a part of the 234th American Chemical Society meeting in 2007. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Galectins includes:
An overview of early galectin research
An explanation of the nature of galectins
A discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cell
An exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity
A discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistance
An introduction to new approaches to designing galectin inhibitors
This is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers.
Contents
Preface vii
Contributors ix
1 Stumbling on Galectins 1
Samuel H. Barondes
2 Galectins and Their Functions in Plain Language 9
Anatole A. Klyosov
3 Understanding Galectin Structure-Function Relationships to Design Effective Antagonists 33
Irina V. Nesmelova, Ruud P.M. Dings, and Kevin H. Mayo
4 Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design 71
Hans-Joachim Gabius and Albert M. Wu
5 Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing 87
John L. Wang, Kevin C. Haudek, Patricia G. Voss, and Ronald J. Patterson
6 Galectins in Regulation of Inflammation and Immunity 97
Fu-Tong Liu, Daniel K. Hsu, Ri-Yao Yang, Huan-Yuan Chen, and Jun Saegusa
7 Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of "Alarmins"? 115
Sachiko Sato and Gabriel A. Rabinovich
8 The Role of Galectins in Organ Fibrosis 147
Neil C. Henderson and Tariq Sethi
9 Galectin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance 157
Florence Lefranc, Marie Le Mercier, Ve'ronique Mathieu, and Robert Kiss
10 Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia 193
James C. Byrd and Robert S. Bresalier
11 Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options 223
Herwig M. Strik and Anna Hoffmann
12 Food-Related Carbohydrate Ligands for Galectins 235
Valeri V. Mossine, Vladislav V. Glinsky, and Thomas P. Mawhinney
Index 271
