Full Description
METABOLIC SYNDROME A comprehensive look at the fight against the metabolic syndrome epidemic
Increasing risk of cardiovascular disease and diabetes, the metabolic syndrome is a world health problem that demands attention from all levels of the health care industry. Metabolic Syndrome: Underlying Mechanisms and Drug therapies extensively covers the metabolic syndrome with an emphasis on drug discovery efforts, providing a context of molecular mechanisms and drug pharmacology for pharmaceutical scientists.
The book starts by examining the physiology of metabolic tissues under normal and disease states, followed by discussions of metabolic diseases and clinical complications. The development of drug therapies based on emerging science is then covered extensively. In addition, there is an in-depth look into the metabolic pathways and dysfunctions in metabolic disease, especially type 2 diabetes and lipid disorders. Finally, a chapter is devoted to past successes and failures in metabolic drug discovery as well as an outlook on future development and challenges.
Divided into four parts, the book:
Addresses important metabolic syndrome basics at the psychological level and metabolic abnormalities at the tissue and pathway levels
Covers the identification of pathways and molecular targets for the development of anti-diabetic therapies
Details pharmaceutical industry approach to solving metabolic and obesity related problems
Describes drug therapies and their limitations and complications, offering a "lessons learned" from existing treatments
With a clear organization and extensive collection of references, the book is a user-friendly and unique tool for scientists in a variety of scientific disciplines in the pharmaceutical and biotechnology industries.
Contents
Introduction ix
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Contributors xi
Part One The Physiology of Metabolic Tissues Under Normal and Disease States
1. Gut as an Endocrine Organ: the Role of Nutrient Sensing in Energy Metabolism 3
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2. Central Glucose Sensing and Control of Food Intake and Energy Homeostasis 29
Lourdes Mounien and Bernard Thorens
3. Abnormalities in Insulin Secretion in Type 2 Diabetes Mellitus 53
Taly Meas and Pierre-Jean Guillausseau
4. Adipokine Production by Adipose Tissue: A Novel Target for Treating Metabolic Syndrome and its Sequelae 73
Vanessa DeClercq, Danielle Stringer, Ryan Hunt, Carla G. Taylor, and Peter Zahradka
5. Hepatic Metabolic Dysfunctions in Type 2 Diabetes: Insulin Resistance and Impaired Glucose Production and Lipid Synthesis 133
Ruojing Yang
6. Energy Metabolism in Skeletal Muscle and its Link to Insulin Resistance 157
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Part Two Metabolic Diseases and Current Therapies
7. Mechanisms and Complications of Metabolic Syndrome 179
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8. Emerging Therapeutic Approaches for Dyslipidemias Associated with High LDL and Low HDL 199
Margrit Schwarz and Jae B. Kim
9. Mechanism of Action of Niacin: Implications for Atherosclerosis and Drug Discovery 235
Devan Marar, Shobha H. Ganji, Vaijinath S. Kamanna, and Moti L. Kashyap
10. Current Antidiabetic Therapies and Mechanisms 253
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Part Three Drug Targets for Antidiabetic Therapies
11. GLP-1 Biology, Signaling Mechanisms, Physiology, and Clinical Studies 281
Remy Burcelin, Cendrine Cabou, Christophe Magnan, and Pierre Gourdy
12. Dipeptidyl Peptidase IV Inhibitors for Treatment of Diabetes 327
C.H.S. McIntosh, S.-J. Kim, R.A. Pederson, U. Heiser, and H.-U. Demuth
13. Sodium Glucose Cotransporter 2 Inhibitors 359
Margaret Ryan and Serge A. Jabbour
14. Fibroblast Growth Factor 21 as a Novel Metabolic Regulator 377
Radmila Micanovic, James D. Dunbar, and Alexei Kharitonenkov
15. Sirtuins as Potential Drug Targets for Metabolic Diseases 391
Qiang Tong
16. 11β-Hydroxysteroid Dehydrogenase Type 1 as a Therapeutic Target for Type 2 Diabetes 423
Clarence Hale and David J. St. Jean, Jr.
17. Monoclonal Antibodies for the Treatment of Type 2 Diabetes: A Case Study with Glucagon Receptor Blockade 459
Hai Yan, Wei Gu, and Murielle Veniant-Ellison
Part Four Lessons Learned and Future Outlook
18. Drug Development for Metabolic Diseases: Past, Present and Future 471
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Index 489
