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基本説明
合成化学の第一人者、コーリー教授による、化学、生物学、新薬開発、医学を統合した初のテキスト。美しい図版を豊富に収録し、現代医学における最重要分子100件以上について、その発見、応用、作用を解説。抗血栓薬、抗生物質からバイアグラまで、対象となる疾患や、薬品の工業製品としての発展、人体への作用や副作用を取り扱い、分子の構造図を描く医薬品ごとに収録。
Contents - INFLAMMATORY, CARDIOVASCULAR AND METABOLIC DISEASES (Anti-Inflammatory Agents, Receptors and Signaling..); REPRODUCTIVE MEDICINE (Osteoporosis, Glaucoma and Antiulcer Agents); AUTOIMMUNE DISEASE AND ORGAN TRANSPLANT.(Immunosuppresive Agents, Infectious Diseases...); MALIGNANT DISEASE. (An Overview of Cancer, Capecitabine (Xeloda)...); DRUGS ACTING ON THE NERVOUS SYSTEM (Pain and Analgesia, Hypnotics (Insomnia) and Antismoking..)
Full Description
Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.
Contents
Part I.
Introduction 2
Understanding Structural Diagrams of Organic Molecules 4
Some Common Molecules 23
Proteins and Three-Dimensional Protein Structure 26
Some of the Protein Structures That Appear in This Book 32
Part II. Inflammatory, Cardiovascular and Metabolic Diseases
Anti-Inflammatory Agents
Acetylsalicylic acid (AspirinTM) 38
Naproxen (AleveTM) 39
How Do Anti-Inflammatory Drugs Work? 40
Other Eicosanoids in Inflammation 41
An Overview of Inflammation 42
Celecoxib (CelebrexTM) 43
Prednisone (DeltasoneTM) 44
Methotrexate (TrexallTM) 46
Allopurinol (ZyloprimTM) 47
Antiasthmatic and Antiallergic Agents
Salmeterol (SereventTM) 50
Fluticasone Propionate (FloventTM) 51
Montelukast Sodium (SingulairTM) 52
Tiotropium Bromide (SpirivaTM) 53
Loratadine (ClaritinTM) 54
Type 2 Diabetes
An Overview of Metabolic Syndrome 56
Antidiabetic and Cholesterol-Lowering Agents
Metformin (GlucophageTM) 60
Glipizide (GlucotrolTM) 61
Pioglitazone (ActosTM) 62
Sitagliptin (JanuviaTM) 63
Atorvastatin (LipitorTM) 64
Ezetimibe (ZetiaTM) 65
Cardiovascular Agents
Atenolol (TenorminTM) 68
Enalapril (VasotecTM) 69
Candesartan Cilexetil (AtacandTM) 70
Aliskiren (TekturnaTM) 71
Amlodipine (NorvascTM) 72
Nitroglycerin 73
Clopidogrel Bisulfate (PlavixTM) 74
Digoxin (LanoxinTM) 75
Receptors and Signaling
Information Flow into the Cell by Chemical Signaling 78
References for Part II 80
Part III. Reproductive Medicine
Oral Contraceptives 90
Testosterone 91
Mifepristone (MifeprexTM) 92
Oxytocin (OxytocinTM) 93
Sildenafil (ViagraTM) 94
Osteoporosis
Some Aspects of Osteoporosis 96
Alendronate (FosamaxTM) 97
Calcitriol (RocaltrolTM) 98
Raloxifene (EvistaTM) 99
Teriparatide (ForteoTM) 100
Glaucoma and Antiulcer Agents
Latanoprost (XalatanTM) 102
Ranitidine (ZantacTM) 103
Omeprazole (PrilosecTM) 104
References for Part III 105
Part IV. Autoimmune Disease and Organ Transplant
A Brief Survey of the Immune System 112
Immunosuppressive Agents
Azathioprine (ImuranTM) 122
Mycophenolate Mofetil (CeIlCeptTM) 123
Cyclosporin (NeoralTM) 124
Tacrolimus (PrografTM) 125
FTY720 (Fingolimod) 126
Infectious Diseases
Antibiotics
Amoxicillin (AmoxilTM) 130
Cefaclor (CeclorTM) 132
Doxycycline (VibramycinTM) 133
Azithromycin (ZithromaxTM) 134
Ciprofloxacin (CiproTM) 135
Trimethoprim (TriprimTM) 136
Amikacin (AmikinTM) 137
Vancomycin (VancocinTM) 138
Linezolid (ZyvoxTM) 139
Isoniazid (LaniazidTM) 140
Ancillary Antibiotics 142
Drug Resistance 143
Antiviral Agents
On Viruses and Viral Diseases 146
Acyclovir (ZoviraxTM) 148
Ribavirin (VirazoleTM) 149
Oseltamivir (TamifluTM) 150
Zidovudine (Retrovir, AZTTM) 151
Zalcitabine (HividTM) 152
Nevirapine (ViramuneTM) 153
Efavirenz (SustivaTM) 154
Lopinavir + Ritonavir (KaletraTM) 155
UK427857 (Maraviroc) 156
Antifungal Agents
Amphotericin (FungizoneTM) 160
Fluconazole (DiflucanTM) 161
Caspofungin (CancidasTM) 162
Terbinafine (LamisilTM) 163
Antimalarial and Antiparasitic Agents
Parasitic Diseases: A Focus on Malaria 166
Chloroquine (ArdenTM) 167
Artemether + Lumefantrine (CoArtemTM) 168
Atovaquone + Proguanil (MalaroneTM) 169
Miltefosine (I mpavidoTM) 170
Nitazoxanide (AliniaTM) 171
Ivermectin (StromectolTM) 172
References for Part IV 173
Part V. Malignant Disease
An Overview of Cancer 184
Capecitabine (XelodaTM) 187
Carboplatin (ParaplatinTM) 188
Vinblastine (VelbanTM) 189
Paclitaxel (TaxolTM) 190
Cyclophosphamide (CytoxanTM) 191
Tamoxifen (NolvadexTM) 192
Irinotecan (CamptosarTM) 193
Bleomycin (BlenoxaneTM) 194
Imatinib (GleevecTM) 195
Sunitinib (SutentTM) 196
Bortezomib (VelcadeTM) 197
Ancillary Anticancer Agents 198
References for Part V 200
Part VI. Drugs Acting on the Nervous System
Pain and Analgesia
Lidocaine (XylocaineTM) 208
Morphine (AvinzaTM) 209
Acetaminophen (Tylenol TM) 210
Fentanyl (DuragesicTM) 211
Sodium Thiopental (Sodium PentothalTM) 212
Gabapentin (NeurontinTM) 213
Diazepam (ValiumTM) 214
Sumatriptan (ImitrexTM) 215
Hypnotics (Insomnia) and Antismoking
Zolpidem (AmbienTM) 218
Ramelteon (RozeremTM) 219
Varenicline (ChantixTM) 220
The Brain, Neurotransmission and Molecular Neurotransmitters 221
Neurodegenerative and Psychiatric Diseases
Levodopa (LarodopaTM) 224
Donepezil (AriceptTM) 225
Antiepileptic Agents 226
Antianxiety Agents 228
Antidepressants 229
Antipsychotics 232
References for Part VI 233
Glossary 237
Index 249
