バイオ医薬品開発におけるタンパク質の生物物理学的特性評価（第２版） Biophysical Characterization of Proteins in Developing Biopharmaceuticals （2ND）

バイオ医薬品開発におけるタンパク質の生物物理学的特性評価（第２版）<br>Biophysical Characterization of Proteins in Developing Biopharmaceuticals （2ND）

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バイオ医薬品開発におけるタンパク質の生物物理学的特性評価（第２版）
Biophysical Characterization of Proteins in Developing Biopharmaceuticals （2ND）

Houde, Damian J. (EDT)/ Berkowitz, Steven A. (EDT)

ウェブストア価格 ¥52,448（本体¥47,680）
Elsevier Science Ltd（2019/11発売）
外貨定価 US$ 250.00
ポイント 476pt

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製本 Paperback:紙装版/ペーパーバック版／ページ数 586 p.
言語 ENG
商品コード 9780444641731
DDC分類 615.7

Full Description

Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today's industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals.

In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical's developability and the technical decision-making process needed when dealing with biophysical characterization data.

I: Proteins and Biophysical Characterization in the Biopharmaceutical Industry
1. The Complexity of Protein Structure and the Challenges it Poses in Developing Biopharmaceuticals
2. Biophysical Characterization and Its Role in the Biopharmaceutical Industry
3. Biopharmaceutical Industry's Biophysical Toolbox

II: The Selected Biophysical Tools in the Biopharmaceutical Industry
4. An Introduction and Hierarchical Organization of the Biophysical Tool
5. The Value of UV, Fluorescence, and FTIR Spectroscopy in Biopharmaceutical Development
6. Circular Dichroism Spectroscopy for Protein Characterization: Biopharmaceutical Applications
7. Size-Exclusion Chromatograph (SEC) in Biopharmaceutical Process Development
8. Scattering Techniques for the Characterization of Biopharmaceuticals
9. Characterizing Biopharmaceuticals using Analytical Ultracentrifugation
10. Sub-visible and Visible Particle Analysis in Biopharmaceutical Research and Development
11. Differential Scanning Calorimetry in the Biopharmaceutical Sciences
12. Biophysical Mass Spectrometry for Biopharmaceutical Process Development: Focus on Hydrogen/Deuterium Exchange
13. One- and Two-Dimensional NMR Techniques for Biopharmaceuticals
14. Use of Chromatography and Electrophoresis for indirectly assessing Biophysical Characterization

III: Concluding Remarks on the Biophysical Characterization of Biopharmaceuticals
15. Biophysically Characterization of very large Biopharmaceuticals
16. Statistical Analysis of Biophysical Characterization Data
17. Biopharmaceutical Developability
18. Technical Decision-making dealing with Biophysical Characterization Data
19. Biophysical Characterization: An Integral Part of the "Totality of the Evidence" Concept