Full Description
This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Contents
Preface
Stephen Dunnett and Anders Björklund
Transplantation in the Future
Fred H. Gage
Ethical Challenges for Using Human Cells in Clinical Cell Therapy
Göran Hermerén
Banking Stem Cells for Research and Clinical Applications
Glyn Stacey
Survival, Differentiation and Connectivity of Ventral Mesencephalic Dopamine Neurons following Transplantation
Lachlan Thompson and Anders Björklund
Electrophysiological Investigations of Synaptic Connectivity between Host and Graft Neurons
Jan Tønnesen and Merab Kokaia
Nigral Grafts in Animal Models of Parkinson's Disease. Is Recovery beyond Motor Function Possible?
Mariah J. Lelos, Eilís Dowd and Stephen B. Dunnett
L-DOPA- and Graft-Induced Dyskinesia following Transplantation
Emma L. Lane and Christian Winkler
Current Status of Clinical Trials of Neural Transplantation in Parkinson's Disease
Jonathan R Evans, Sarah L Mason and Roger A Barker
In vivo Imaging of the Integration and Function of Nigral Grafts in Clinical Trials
Marios Politis and Paola Piccini
Neuropathology in Transplants in Parkinson's Disease: Implications for Disease Pathogenesis and the Future of Cell Therapy
Patrik Brundin and Jeffrey H. Kordower
Derivation of Dopaminergic Neurons from Pluripotent Stem Cells
Lorenz Studer
Characterization and Criteria of Embryonic Stem and Induced Pluripotent Stem Cells for a Dopamine Replacement Therapy
Oliver Cooper, Malin Parmar and Ole Isacson
Skilled Motor Control for the Preclinical Assessment of Functional Deficits and Recovery following Nigral and Striatal Cell Transplantation
Alexander Klein and Ian Q. Whishaw
Role of Experience, Training and Plasticity in the Functional Efficacy of Striatal Transplants
Máté D. Döbrössy and Guido Nikkhah
In vivo Imaging of Integration and Function of Striatal Grafts in Rodent and Non-Human Primate Animal Models
Philippe Hantraye and Romina Aron Badin
Clinical Trials of Neural Transplantation in Huntington's Disease
Anne E. Rosser and Anne-Catherine Bachoud-Lévi
Derivation of Striatal Neurons from Human Stem Cells Pedro Viegas, Camille Nicoleau and Anselme L. Perrier
