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Full Description
Histone Deacetylases in Neurodegenerative Disease, Part A, Volume 733 in the Methods in Enzymology series, highlights new advances, with this volume presenting chapters on topics such as HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress, Specific activation of p300/CBP Lysine acetyltransferases induces adult neurogenesis and synaptic plasticity, Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis, Histone Deacetylase 6 modulates Tau structure and function, Histone Acetylation in Parkinson Disease, DNA methylation and histone modification in hypoxic conditions, The extracellular Histone Deacetylase 6 modulates the actin networks in neuronal cells, Epigenetic modulators as therapeutics for neurodegenerative disorder/Alzheimer's disease, and much more.
Additional chapters explore Sirtunins in mitochondrial physiology and energy homeostasis, Sirtunins in metabolic homeostasis, Conformational flexibility of histone variant CENP-ACse4 is regulated by histone H4: A mechanism to stabilize soluble Cse4, Analysis of copper toxicity by western blotting of secretory proteins translocated via Sec61 channel, Histone deacetylase as a potential therapeutic target for memory disorders, Histone deacetylases in Neurodegeneration, Role of Deubiquitinases in Regulating Tau Acetylation and Autophagic Clearance in Alzheimer's Disease, Histone deacetylases in Neurodegeneration and neuronal plasticity, and more.
Contents
1. HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress
Christian Marx
2. Specific activation of p300/CBP Lysine acetyltransferases induces adult neurogenesis and synaptic plasticity
Tapas K. Kundu
3. Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis
Raghuvir Singh Tomar, Rakesh Kumar Sahu and Sakshi Singh
4. Histone Deacetylase 6 modulates Tau structure and function
Subashchandrabose Chinnathambi
5. Histone Acetylation in Parkinson Disease
Zhuohua Zhang
6. DNA methylation and histone modification in hypoxic conditions
Sanjeev Shukla
7. The extracellular Histone Deacetylase 6 modulates the actin networks in neuronal cells
Subashchandrabose Chinnathambi
8. Epigenetic modulators as therapeutics for neurodegenerative disorder/Alzheimers disease
Balaram Ghosh
9. Sirtunins in mitochondrial physiology and energy homeostasis
Ullas Kothur-Seetharam
10. Sirtunins in metabolic homestasis
Nagalingam Ravi Sundaresan
11. Conformational flexibility of histone variant CENP-ACse4 is regulated by histone H4: A mechanism to stabilize soluble Cse4
Ashutosh Kumar
12. Analysis of copper toxicity by western blotting of secretory proteins translocated via Sec61 channel
Raghuvir Singh Tomar, Smriti Anand, Prateeksha Thakur, Vandana Anjana, Santoshi Acharjee, Rajshree Pal and Sugandh Sharma
13. Histone deacetylase as a potential therapeutic target for memory disorders
Mahendra Kumar Thakur
14. Histone deacetylases in Neurodegeneration
Amit Mishra
15. Role of Deubiquitinases in Regulating Tau Acetylation and Autophagic Clearance in Alzheimer's Disease
Poornima Priyadarshini
16. Histone deacetylases in Neurodegeneration and neuronal plasticity
Bhupesh Mehta
17. Experimental strategies to evaluate the impact of HDACs on the epigenome: The ChiP-seq
Claudio Brancolini and Martina Minisini
18. Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity
Christian Steinkühler
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