Full Description
Microglial Advances in Neurodegenerative Diseases, Volume 170 of Advances in Immunology series, presents current developments and comprehensive reviews focused on the role of microglia and neuroinflammation in neurological and psychiatric disorders. This volume brings together contributions from leading researchers, offering up-to-date insights into microglial biology in health and disease, as well as their involvement in major neurodegenerative conditions.
Chapters explore microglial interactions with key pathological proteins, including tau and amyloid-beta, mechanisms of neuroinflammation, and receptor-mediated signaling pathways. Additional contributions highlight advances in induced pluripotent stem cell-derived microglia as experimental and therapeutic platforms, neuromodulation strategies, and emerging perspectives on Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and psychiatric disorders. Together, these chapters provide a comprehensive overview of recent progress and emerging directions in microglial research and neurodegeneration.
Contents
1. Cross-talk between Tau and Neuro-glia Axis of Alzheimer's Disease
2. Microglia in Health and Disease
3. Amyloid-beta (Aβ) and Neuroinflammation in Microglia
4. Chemokine Receptor CX3CR1 Interacts with Tau and Regulates Microglial Activity in Alzheimer's Disease
5. Human-Induced Pluripotent Stem Cells in Psychiatric Disorders
6. GPCR-Mediated Internalization and Endosomal Sorting of the Tau-GPCR Complex in Microglia
7. iPSC-Derived Microglia: A Cellular Platform for Tau and Alzheimer's Disease Immunotherapy
8. Advancements in Invasive and Non-Invasive Neuromodulation for Parkinson's Disease
9. LRRK2-I1371V Disrupts Microglial Membrane Homeostasis and Enhances α-Synuclein Toxicity
10. Microglial Advances in Parkinson's Disease
11. Microglial Advances in Alzheimer's Disease
12. iPSC-Derived Microglial Advances in Amyotrophic Lateral Sclerosis (ALS)
13. Glial Advances in Neurodegenerative Diseases
14. Microglial Dynamics and Neuroinflammation in the Early Onset of Parkinson's Disease
15. Microglial Advances in Psychiatric Disorders
16. Astroglial Advances in Neurodegenerative Diseases
17. Neuroinflammation in Parkinson's Disease
