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Full Description
miRNA in Human Disease: From Biomarkers to Therapeutics explores the critical role of microRNAs (miRNAs) in the development and progression of various diseases, emphasizing their significance as biomarkers and therapeutic targets. Sections provide a comprehensive overview of the biogenesis, function, and regulation of miRNAs, offering insights into how these small noncoding RNA molecules influence gene expression and contribute to disease development and progression. The book covers traditional and advanced methods for miRNA extraction, the role of miRNAs in infectious diseases, cancer, neurological disorders, cardiovascular disease, hemoglobinopathies, pregnancy complications, and metabolic disorders.
Sections also discuss the latest research on miRNA-based therapies, including the design and delivery of miRNA mimics and inhibitors and their potential applications in personalized medicine. With a strong focus on practical implementation, the book includes detailed case studies and real-world examples that demonstrate the clinical relevance of miRNA research. It addresses the challenges and future directions in the field, providing a roadmap for researchers, clinicians, and industry professionals to harness the potential of miRNAs for disease diagnosis, treatment, and prevention.
Contents
1. Introduction: miRNA Regulation and Dysregulation
2. Traditional Methods for miRNA Extraction
3. miRNAs in Infectious Disease
4. miRNAs in Cancer
5. miRNAs in Neurological Disorders
6. miRNAs in Cardiovascular Disease
7. miRNAs in Hemoglobinopathy: Sickle Cell Disease
8. miRNA in Placental Development and Pregnancy Complications
9. miRNA in Metabolic Disorders
10. Conclusion and Future Perspectives Appendices
