Full Description
Advancements in mRNA-based therapeutics have transformed the landscape of modern medicine, particularly in vaccine development and gene therapy. However, the challenge of effectively delivering mRNA to target cells remains a significant barrier to widespread clinical application. Lipid Nanoparticles-Based mRNA Delivery System offers a comprehensive exploration of lipid nanoparticles (LNPs), the most promising delivery vehicles for mRNA. This book consolidates current knowledge, identifies research gaps, and provides insights into the latest developments in LNP technologies, making it an essential resource for researchers, pharmaceutical developers, and clinicians at the forefront of mRNA therapeutics. Exploring the intricacies of LNP formulation, the book covers a wide range of topics, including the fundamental principles of lipid nanoparticles, design strategies for effective mRNA encapsulation, and the unique challenges associated with various routes of administration—such as intravenous, oral, transdermal, and intranasal delivery. It also examines the therapeutic applications of lipid-based systems, particularly in vaccines and cancer immunotherapy, while addressing critical challenges like immunogenicity and regulatory considerations. The final sections provide a forward-looking perspective on future trends and innovations in lipid-based mRNA delivery systems, ensuring that readers are well-equipped to navigate this rapidly evolving field. By bringing together contributions from leading experts across the globe, Lipid Nanoparticles-Based mRNA Delivery System not only enhances understanding of lipid-based delivery technologies but also fosters collaboration and innovation in the development of mRNA therapies. This book serves as a tool for advancing the field, ultimately contributing to the broader adoption of mRNA therapeutics in clinical practice and improving patient outcomes worldwide.
Contents
Part I: Foundations of Lipid Nanoparticle (LNP) Technology
1. Introduction to mRNA and RNA Therapeutics
2. Basic Principles of Lipid Nanoparticles (LNPs)
3. Mechanisms of mRNA Delivery via LNPs
Part II: Design and Formulation of Lipid Nanoparticles for mRNA Delivery
4. Lipid Nanoparticle Formulation Strategies
5. Lipid Nanoparticle Characterization
Part III: Administration Routes for Lipid-based mRNA Delivery
6. Intravenous (IV) Administration of mRNA-LNPs
7. Transdermal Administration of mRNA-LNPs
8. Intranasal Administration of mRNA-LNPs
9. Intramuscular Administration of mRNA LNPs
10. Other Emerging Routes of mRNA Delivery
Part IV: Applications of Lipid-based mRNA Delivery Systems
11. mRNA Vaccines: Revolutionizing Preventive Medicine
12. mRNA in Cancer Immunotherapy
Part V: Challenges, Solutions, and Future Directions
13. Immunogenicity and Toxicity of mRNA-LNPs
14. Regulatory Considerations for mRNA-LNP-Based Therapeutics
15. Future Trends in Lipid-based mRNA Delivery
