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Full Description
Advances in Structural Biology: From Protein Structures to Function and Disease offers a comprehensive, practical resource that bridges the latest experimental and computational approaches in structural biology. Backed by real-world case studies, the book demonstrates how these technologies can be utilized to serve a range of biological needs. The content spans foundational principles of protein structure and bioinformatics tools, cutting-edge methodologies such as MicroED and Cryo-EM, and the transformative role of artificial intelligence and big data analytics in structural biology. It also considers applications including drug discovery, vaccine development, antiviral therapy, personalized medicine, and the structural basis of aging and neurodegenerative diseases.
Readers will find detailed investigation into the latest developments in structural and computational biology, including insights into integrative methodologies that combine both traditional and emerging technologies. This resource is invaluable for advanced students, researchers, and professionals aiming to harness structural biology for innovative solutions in precision medicine and translational research.
Contents
Section I: Foundations: Computational and Conceptual
1. Unraveling Protein Function with Structural Biology Approaches
2. Bioinformatics Tools for Protein Modeling in Neurodegenerative Diseases
3. Bioinformatics Tools for Protein Modeling in Cancer
4. Unravelling protein folding and structural dynamics
Section II: Methodologies: Experimental and Integrative Techniques
5. Cryo-Electron Microscopy: Unlocking Protein Structures in Disease Biology
6. Computational and AI Methodologies for Big Data Analytics in Structural Biology
7. Big Data Analytics in Structural Biology and Bioinformatics
8. AI and machine learning in structural biology
9. Integrating structural and omics data for drug discovery
Section III: Applications
10. Applications of structural biology in drug discovery
11. Structural biology approaches in vaccine development
12. Structural Insights into Antiviral Drug Design: From Viral Targets to Therapeutic Leads
13. Structural bioinformatics in personalized medicine
14. Structural biology in understanding bacterial resistance
15. Structural biology approaches in Neurodegeneration and Aging
16. Structural biology of protein misfolding and aggregation in disease
17. Integrated structural approaches in immunotherapy
Section IV: Translational Biology
18. Structural and systems biology in cancer therapy
19. Structural biology in precision medicine and clinical translation
20. Future trends in structural biology
