Full Description
Advanced Cancer Therapeutics: Strategies and Technologies for Targeted Drug Delivery explores the heterogeneity of tumors and microenvironmental factors that influence cancer treatment and contribute to drug resistance. The book discusses critical elements such as tumor stroma, vasculature, pH, hypoxia, and enzymatic activity that impact therapeutic efficacy. Sections cover advanced drug formulations, including supramolecular systems, metal-organic frameworks, and nanomedicine, focusing on their roles in selective drug delivery for early detection, diagnosis, and treatment of various cancers. In addition, it reviews the current status and future perspectives of these formulations, highlighting their potential to enhance therapeutic outcomes while minimizing side effects.
Readers will also find discussions on the limitations of nanocarriers, along with regulatory and ethical considerations related to anticancer formulations. This resource is invaluable for researchers, clinicians, and students, offering insights into the latest advancements in drug delivery systems.
Contents
I. UNDERSTANDING THE CANCER
1. Introduction to cancer
2. Current practices in cancer chemotherapy
3. Emerging trend in anticancer drug delivery
4. Cancer therapy depending on tumor stroma
5. Cancer therapy depending on cancer cell respiration: pH and hypoxia
6. Cancer therapy depending on tumor vasculature and EPR effects.
7. Cancer therapy based on extracellular matrix
8. Heterogenicity of cancer and drug resistance
II. STRATEGIES AND TECHNOLOGIES FOR CANCER THERAPY
9. Materials and strategies for advanced anticancer drug delivery
10. Drug Conjugates for anticancer drug delivery
11. Self-assembled supramolecular systems for anticancer drug delivery
12. Advances in metal-organic frameworks for anticancer drug delivery
13. Tumor microenvironment targeted drug delivery systems
14. Advances in dendrimers for anticancer drug delivery
15. Advances in metallic nanoparticles for anticancer drug delivery
16. Advances in polymeric nanoparticles for anticancer drug delivery
17. Advances in lipid-based nanoparticles for anticancer drug delivery
18. Advances in SNEDDS for anticancer drug delivery
19. Advances in nanocrystals for anticancer drug delivery
20. Theranostic nanoparticles for advanced cancer therapy
21. DNA-based nanomaterials for anticancer therapy
22. Nanofibrous scaffolds for cancer management
23. Advances in hydrogel for anticancer drug delivery
24. Advances in inorganic nanocarriers for anticancer drug delivery
25. Microparticles for anticancer drug delivery
26. Microneedles for anticancer drug delivery
27. Implants for anticancer drug delivery
28. Phytomedicine for cancer therapy
29. Enzyme-prodrug as advanced cancer therapeutics
III. CLINICAL STATUS, CHALLENGES AND FUTURE PROSPECTIVES
30. Clinical status of anticancer drug delivery systems
31. Challenges and future prospectives in anticancer drug delivery
32. Regulatory considerations for anticancer drug delivery systems
