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Full Description
Advanced Drug Delivery Systems for Targeted Cancer Therapy explores the heterogeneity of tumors and microenvironmental factors that influence cancer treatment and contribute to drug resistance. It discusses critical elements such as tumor stroma, vasculature, pH, hypoxia, and enzymatic activity that impact therapeutic efficacy. The book covers advanced drug formulations, including supramolecular systems, metal-organic frameworks, and nanomedicine, focusing on their roles in selective drug delivery for early detection, diagnosis, and treatment of various cancers. It reviews the current status and future perspectives of these formulations, highlighting their potential to enhance therapeutic outcomes while minimizing side effects. Additionally, it examines the limitations of nanocarriers and addresses regulatory and ethical considerations related to anticancer formulations. This resource is invaluable for researchers, clinicians, and students, offering insights into the latest advancements in drug delivery systems. It bridges the gap between conventional and innovative therapies, equipping the audience with essential knowledge for developing precise cancer treatment strategies.
Contents
I. UNDERSTANDING THE CANCER
1. Introduction to cancer
2. Current practices in cancer chemotherapy
3. Emerging trend in anticancer drug delivery
4. Cancer therapy depending on tumor stroma
5. Cancer therapy depending on cancer cell respiration: pH and hypoxia
6. Cancer therapy depending on tumor vasculature and EPR effects.
7. Cancer therapy based on extracellular matrix
8. Heterogenicity of cancer and drug resistance
II. STRATEGIES AND TECHNOLOGIES FOR CANCER THERAPY
9. Materials and strategies for advanced anticancer drug delivery
10. Drug Conjugates for anticancer drug delivery
11. Microparticles for anticancer drug delivery
12. Self-assembled supramolecular systems for anticancer drug delivery
13. Advances in metal-organic frameworks for anticancer drug delivery
14. Nanotechnology for anticancer drug delivery: possibilities and limitations
15. Tumor microenvironment targeted drug delivery systems
16. Advances in dendrimers for anticancer drug delivery
17. Advances in metallic nanoparticles for anticancer drug delivery
18. Advances in polymeric nanoparticles for anticancer drug delivery
19. Advances in lipid-based nanoparticles for anticancer drug delivery
20. Advances in SNEDDS for anticancer drug delivery
21. Advances in nanocrystals for anticancer drug delivery
22. Theranostic nanoparticles for advanced cancer therapy
23. Advances in hydrogel for anticancer drug delivery
24. Nanofibrous scaffolds for cancer management
25. Genetic nanomaterials for anticancer drug delivery
26. Organic nanocarriers for anticancer drug delivery
27. Microneedles for anticancer drug delivery
28. Implants for anticancer drug delivery
29. Phytoconstituents based anticancer drug delivery systems
III. CLINICAL STATUS, CHALLENGES AND FUTURE PROSPECTIVES
30. Clinical status of anticancer drug delivery systems
31. Challenges and future prospectives in anticancer drug delivery
32. Regulatory considerations for anticancer drug delivery systems
