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Full Description
Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways: Synergistic Approaches in Gastrointestinal Cancer Treatment offers a detailed examination of the biological complexities driving gastrointestinal (GI) cancers, including colorectal, gastric, liver, and pancreatic malignancies. By synthesizing the latest research, this book addresses the critical demand for innovative treatments in GI oncology. It explores the interconnections between DNA repair mechanisms, tumor genetics, and essential cellular signaling pathways, revealing their significance in cancer progression and therapeutic intervention. Insightful discussions highlight how these molecular aspects contribute to personalized medicine, paving the way for more effective, individualized strategies to combat GI cancers.
Additionally, the book stands out by illustrating the benefits of combining targeted therapies, which can enhance overall treatment effectiveness and help overcome clinical resistance. Real-world case studies and contributions from leading experts provide a practical bridge between laboratory discoveries and clinical practice. This comprehensive resource encourages collaboration among researchers and clinicians, promoting a holistic approach to understanding GI cancer biology.
Contents
1. Introduction to Gastrointestinal Cancers: An Overview of Current Challenges
2. Understanding DNA Repair Mechanisms: The Key Players in Genomic Stability
3. The Genetic Landscape of Gastrointestinal Tumors: Key Alterations and Pathways
4. The Role of Signaling Pathways in Tumorigenesis
5. The Role of DNA Damage Response in Cancer Progression
6. Synergistic Approaches in GI Cancer Therapy: Concepts and Strategies
7. Targeting DNA Repair and Signaling Pathways: A Novel Paradigm in Gastrointestinal Cancer Treatment
8. Inhibiting Homologous Recombination: Therapeutic Implications in GI Cancers
9. The Role of PARP Inhibitors in Enhancing Chemotherapy Efficacy
10. Exploiting the Synthetic Lethality Concept in Gastrointestinal Tumors
11. Combination Therapies: Chemotherapy and DNA Repair Inhibition in GI Cancers
12. Immunotherapy and DNA Repair: A Dual Approach to Combat GI Cancers
13. Radiation Therapy: Targeting DNA Repair Mechanisms for Enhanced Outcomes
14. Emerging Biomarkers: Predicting Response to DNA Repair and Signaling Targeting Therapies
15. Clinical Trials: Evidence for Synergistic Approaches in GI Cancer Treatment
16. Future Directions: Novel Targets and Strategies in DNA Repair, Signaling for GI Cancers
17. Integrating Genomics with Immunotherapy for GI Cancers: A Synergistic Approach
18. Conclusion: Integrating Synergistic Approaches for Personalized GI Cancer Treatment
