Full Description
Kinase Targets and Drug Discovery covers the critical role of kinases as regulators of cellular functions and their implications in a range of diseases, from cancers to cardiovascular disorders and inflammatory conditions. Readers will explore foundational concepts on the functions of kinases, the role of kinase inhibitors in disease therapy, and challenges faced. The second section focuses on innovative strategies in kinase drug discovery, covering screening and computational approaches, along with the development of covalent, macrocyclic, allosteric inhibitors, and kinase degraders. Final sections examine clinical applications, detailing how kinase inhibition can be harnessed for cancer therapies, non-oncologic diseases, and even non-catalytic functions.
This book will serve as an indispensable resource for pharmacologists, medicinal chemists, and researchers in both academia and industry. By bridging the gap between foundational research and clinical application, it equips professionals with the latest insights and practical approaches to advance their understanding to contribute meaningfully to the evolving landscape of drug discovery.
Contents
Part I: Kinase as drug target: An overview
1. Introduction to Kinases and Their Functions
2. Kinase Inhibitors in Diseases Therapy
3. Challenges in Kinase Inhibitors Discovery
Part II: Strategies in Kinase Drug Discovery
4. Screening Approaches for Kinases
5. Computational Approaches for Kinases
6. Covalent Inhibitors of Kinase
7. Macrocyclic Inhibitors of Kinase
8. Allosteric Inhibitors of Kinase
9. Kinase Degraders
10. Kinase Activators
Part III: Clinical Indications for Kinase Inhibitors
11. Kinase Inhibition for Cancer (Contain Immuno-Oncology)
12. Kinase Inhibition for Nononcologic Diseases
13. Kinase Inhibition for Non-Catalytic Function
