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Full Description
Lipids are the cell's hydrophobic metabolites, and their self-assembly into bilayers creates membranes that are critical barriers and organizing platforms in cells. Lipids are a chemically diverse set of biological molecules subject to rapid metabolism and transport, and this dynamic behavior has motivated the development of methods across multiple disciplines for their detection and manipulation. Split into three parts, the Volumes on Lipids and Membranes provide a broad snapshot of the state of the art of methods for studying biological lipids and biomembranes. This part focuses on techniques for probing lipid and membrane dynamics, including interorganelle lipid transport.
Contents
1. De novo chemoenzymatic construction of lipid membranes
Alessandro Fracassi
2. Photoaffinity labeling for cholesterol metabolism
Alison Ondrus
3. Expression and Characterization of Phospholipase Cb and Ce enzymes
Angeline Lyon
4. Assembling Retromer-coated membrane tubules for in vitro structure-function studies
Brett Collins
5. Quantative analysis of S-acylation
Gemma Triola
6. Inhibition of palmitoyltransferases
Hening Lin
7. Exploiting protein lipidation to create peptide-based biomaterials
James Hougland
8. Optogenetic control of lipid-modifying enzyme activity using LOV domain insertions
Jeremy Baskin
9. Chemoproteomics approaches for inhibition of diacylglycerol kinases
Ku-Lung (Ken) Hsu
10. Inhibition of sterol transfer protein function
Luca Laraia
11. Preparation of K-Ras4B containing synthetic modifications via expressed protein ligation
Mark Distefano
12. Regulation of lipin enzymes on membranes
Michael Airola
13. Use of novel synthetic analogues to decipher the interactions of phosphatidic acids species
Nicolas Vitale
14. Analyzing lipid-nuclear receptor interactions
Raymond Blind
15. Supported lipid bilayers for viral protein lipid interactions
Robert Stahelin
16. Palmitoylation-dependent probes for labeling the Golgi complex
Shinya Tsukiji
17. A real-time assay for lipidation of ATG8/LC3 using fluorerscence spectroscopy
Taki Nishimura
18. Optogenetic Phospholipase C for Measuring Phosphoinositide Turnover and DAG Generation
Toshihisa Ohtsuka
19. Targeting protein palmitoylation
Will Fuller
20. Pharmacological modulation of lipid metabolism
Wonhwa Cho
