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Full Description
This comprehensive volume explores the diverse mechanisms and methodologies underlying cell death, providing an up-to-date resource for researchers and clinicians in the biomedical sciences. The book brings together leading experts to discuss both established and emerging approaches for studying cell death, with a strong emphasis on practical laboratory techniques and their applications in disease research and drug discovery.
Contents
1. Methodologies for Monitoring Alkaliptosis in Cancer Cells
Daolin Tang
2. Protein-complementation assay and DISC analysis
PATRICK LEGEMBRE, dhouha Msalbi and Eden Lebrault
3. Detecting phosphorylated MLKL in murine tissues
Riley M. Williams, Siddharta Balachandran and Bikash Thapa
4. Establishment of different cell death models (Apoptosis, Necroptosis, Pyroptosis)
Dai Chao Xu and Yuanxing Yang
5. Implementation of the FENIX assay to determine anti-ferroptotic properties of test compounds
Markus Morrison, Juliana Huether, Melodie Mallais and Derek A. Pratt
6. CRISPR-Cas9 knockout screens to identify drug resistance genes in Acute Myeloid Leukemia
Cai Huan
7. Cell death assays for the detection of acute kidney tubular necrosis
Andreas Linkermann and Francesca Maremonti
8. Methods of cell death imaging by Incucyte and similar platforms
Ivano Amelio
9. Super-resolution microscopy-based assessment of organellar redox-active iron distribution and its relevance for ferroptosis
Patrizia Agostinis, Francesca Rizzollo, Charlotte Cresens, Benjamin Pavie and Pablo Hernandez-Varas
10. Monitoring inflammasome activation by analysing ASC specks and oligomerisation
Sharad Kumar
11. LPS-induced sepsis/ and TNF-induced SIRS (In vivo cell death models)
Dai Chao Xu and Jianling Liu
12. Evaluating protease activation and inactivation of gasdermin cell death effectors
Christopher LaRock and Doris LaRock
13. Measurement of plasma membrane rupture via confocal microscopy
Fiachra Humphries
