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Full Description
Cell Death, Part A, Volume 205 explores the diverse mechanisms and methodologies underlying cell death, providing an up-to-date resource for researchers and clinicians in the biomedical sciences. Chapters in this new release include Methodologies for Monitoring Alkaliptosis in Cancer Cells, Protein-complementation assay and DISC analysis, Detecting phosphorylated MLKL in murine tissues, Establishment of different cell death models (Apoptosis, Necroptosis, Pyroptosis), Implementation of the FENIX assay to determine anti-ferroptotic properties of test compounds, CRISPR-Cas9 knockout screens to identify drug resistance genes in Acute Myeloid Leukemia, and much more.
Additional chapters cover Cell death assays for the detection of acute kidney tubular necrosis, Methods of cell death imaging by Incucyte and similar platforms, Super-resolution microscopy-based assessment of organellar redox-active iron distribution and its relevance for ferroptosis, Monitoring inflammasome activation by analyzing ASC specks and oligomerization, LPS-induced sepsis/ and TNF-induced SIRS (In vivo cell death models), Evaluating protease activation and inactivation of gasdermin cell death effectors, and Measurement of plasma membrane rupture via confocal microscopy.
Contents
1. Methodologies for Monitoring Alkaliptosis in Cancer Cells
Daolin Tang
2. Protein-complementation assay and DISC analysis
PATRICK LEGEMBRE, dhouha Msalbi and Eden Lebrault
3. Detecting phosphorylated MLKL in murine tissues
Riley M. Williams, Siddharta Balachandran and Bikash Thapa
4. Establishment of different cell death models (Apoptosis, Necroptosis, Pyroptosis)
Dai Chao Xu and Yuanxing Yang
5. Implementation of the FENIX assay to determine anti-ferroptotic properties of test compounds
Markus Morrison, Juliana Huether, Melodie Mallais and Derek A. Pratt
6. CRISPR-Cas9 knockout screens to identify drug resistance genes in Acute Myeloid Leukemia
Cai Huan
7. Cell death assays for the detection of acute kidney tubular necrosis
Andreas Linkermann and Francesca Maremonti
8. Methods of cell death imaging by Incucyte and similar platforms
Ivano Amelio
9. Super-resolution microscopy-based assessment of organellar redox-active iron distribution and its relevance for ferroptosis
Patrizia Agostinis, Francesca Rizzollo, Charlotte Cresens, Benjamin Pavie and Pablo Hernandez-Varas
10. Monitoring inflammasome activation by analysing ASC specks and oligomerisation
Sharad Kumar
11. LPS-induced sepsis/ and TNF-induced SIRS (In vivo cell death models)
Dai Chao Xu and Jianling Liu
12. Evaluating protease activation and inactivation of gasdermin cell death effectors
Christopher LaRock and Doris LaRock
13. Measurement of plasma membrane rupture via confocal microscopy
Fiachra Humphries
