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Full Description
Genome Damage: Repair and Adaptation across Life explores the significance of nucleic acid damage from environmental pollutants, UV radiation and other stressors, which can lead to mutations, genetic instability, and various diseases, including cancer. This book delves into the mechanisms of DNA and RNA repair, which are crucial for maintaining cellular health and enabling evolutionary adaptations. The book examines these intricate processes across microbes, plants, and animals, providing a comprehensive understanding of how genetic materials are regulated and repaired under diverse environmental conditions. It covers a wide range of topics, including advanced molecular mechanisms of nucleotide repair, UV-induced damage, apoptosis cell death and autophagy, genetic instability in crops, and the role of post-translational modifications in DNA repair. The text also explores the detection and quantification of DNA damage, the impact of synthetic chemicals and climate change on nucleic acids, and the therapeutic significance of DNA repair mechanisms. The book closes with a look towards future perspectives. Genome Damage: Repair and Adaptation across Life is an invaluable resource for students, researchers, and professionals in molecular biology, cytogenetics, genomics, microbiology, ecotoxicology, plant biotechnology and the pharmaceutical industry. It is particularly beneficial for those studying the molecular mechanisms of DNA damage from an evolutionary perspective and those developing therapeutic strategies for cancer, oxidative diseases, and aging-related disorders.
Contents
1. Genome research: basic concept and recent advances
2. Nucleotide repair mechanism: fundamental to molecular advances
3. Nucleotide damage and its role in the evolution of microbes
4. UV mediated damage and repair in bacterial communities
5. Oxidative stress and nucleotide mutagenesis in microbes
6. DNA Photolyase: Properties and mode of action
7. DNA repair in extremophiles
8. Genetic instability in crop plants: evolution and modern perspectives
9. UV-induced DNA damage and repair in higher plants
10. Ionizing radiation induced mammalian cell damage and repairs
11. Non ionizing radiation induced DNA damage and repair in animals
12. Oxidative DNA damage: repair mechanisms and associated disorder in humans
13. Responses of cell checkpoint on DNA mutagenesis
14. DNA damage and autophagy: mechanisms and significance
15. Role of Post translational modification in DNA repair
16. Detection of DNA damage and repair: a technological development
17. Cellular quantification of DNA damage and its repair
18. Eco-toxicity of synthetic chemicals and DNA health
19. Effects of climate change on nucleic acid composition
20. RNA damage and repair mechanism
21. DNA damage and cancer: advances, risk assessment and opportunities
22. Metal stress and DNA mutagenesis
23. Recent development in photonic induced photorepair mechanism
24. Apoptosis cell death and DNA damage
25. Significance of plant nutraceuticals in DNA repair
26. Significance of algal green chemicals in repair mechanism
27. DNA damage and repair: a disease specific therapeutic significance
28. DNA damage and aging: Concept, feasibility, and significance
29. SOS response and molecular check point repair
30. DNA damage and recombination repair during DNA replication
31. Structural and dynamical signatures of DNA damage
32. Impacts of nanoparticles on DNA damage and repair
33. Bioprospecting of active metabolites for repair of DNA damage
34. DNA photosensitization-application and future perspectives
35. DNA damage and repair: Future perspectives
