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Full Description
Artificial Metalloproteins covers artificial metalloproteins (ArMs) and how they have emerged as powerful vehicles with which to control, implement, and leverage the unique reactivity and spectroscopic properties of their bound metal ions. Chapters in this release include Incorporating Non-Native Cofactors into Heme Proteins, Designing 4-Helix Bundles to Bind Porphyrin/Porphyrin-like Cofactors, Cobalt-Substituted Hemoprotein Expression, Rationally designed directed evolution of cytochrome P450 enzymes, De novo design of a switchable a-helical hemoprotein, Primary Coordination Sphere Part B: Unnatural Metal-Binding Sites Beyond the Heme, and more.
Other sections cover Unnatural Amino Acid Incorporation for Creating Artificial Metalloenzymes, Development of a PQQ-Dependent Artificial Metalloprotein, Evolutionary Engineering of a Rhodium Complex-Linked Artificial Metalloenzyme, Design and Application of Nonheme Iron Enzymes, Part C: Secondary Sphere Modulation for Metallocofactor Activation, Designing Artificial Metalloenzymes by Engineering the Primary and Secondary Coordination Sphere in Native Protein Scaffolds, and much more.
Contents
1. Incorporating Non-Native Cofactors into Heme Proteins
Christopher Lemon
2. Designing 4-Helix Bundles to Bind Porphyrin/Porphyrin-like Cofactors
Samuel Mann
3. Cobalt-Substituted Hemoprotein Expression
Andrew Buller
4. Rationally designed directed evolution of cytochrome P450 enzymes
Shyamalava Mazumdar
5. De novo design of a switchable ??-helical hemoprotein
Vincent Louis Pecoraro
Primary Coordination Sphere Part B: Unnatural Metal-Binding Sites Beyond the Heme
6. Unnatural Amino Acid Incorporation for Creating Artificial Metalloenzymes
Woon Ju Song
7. Development of a PQQ-Dependent Artificial Metalloprotein
Lisa Olshansky
8. Evolutionary Engineering of a Rhodium Complex-Linked Artificial Metalloenzyme
Akira Onoda
9. Design and Application of Nonheme Iron Enzymes
Xiongyi Huang
Part C: Secondary Sphere Modulation for Metallocofactor Activation
10. Designing Artificial Metalloenzymes by Engineering the Primary and Secondary Coordination Sphere in Native Protein Scaffolds
Yi Lu
11. De Novo-Designed Artificial Cu Proteins and Electron Transfer
Saumen Chakraborty
12. Design and Evaluation of Biocatalysts for Energy-Related Reactions
Kara Bren
Part D. Superstructural Control: Tertiary and Quaternary Effects in Metalloprotein Design
13. Breaking Symmetry: Metal-Guided Assembly of Heterotrimeric Coiled Coils
Vincent Louis Pecoraro and Salvatore La Gatta
14. Engineering Conformationally Switchable Artificial Metalloproteins
Lisa Olshansky
15. Chemical Methods to Stabilize Segments of Metalloproteins in the Form of Peptides
Andy Nguyen
16. Design and Production of De Novo Protein Nanowires
Ross Anderson
