Full Description
Immunity to Immunotherapy in Cancer: Mechanisms and Limitations explores the intricate interplay between cancer therapy and the immune system, addressing why some patients do not respond to immunotherapy and the scientific solutions in development. The book examines molecular strategies of immune evasion within the tumour microenvironment, providing insights into factors like tumour heterogeneity and immune checkpoint mechanisms that contribute to resistance. Highlighting promising approaches such as combination therapies, personalized medicine, and novel immunotherapeutic agents, it aims to enhance patient outcomes and advance cancer immunotherapy. Designed as a comprehensive guide for professionals and researchers, this textbook offers an overview of the latest scientific discoveries and practical applications in cancer therapy. It serves as an invaluable resource for scientists, doctors, academicians, and students, presenting a path toward more effective, non-toxic, and customized cancer treatments. This book is essential for anyone interested in the future of cancer therapy.
Contents
Part A: Cancer Immunity
1. Introduction to Immunity in Cancer
2. Role of Innate Immunity in Cancer Immunology
3. Role of Dendritic Cells in Cancer Immunology
4. Role of Natural Killer Cells in Cancer Immunology
5. Role of B-Cells in Tumor Immunity
6. Role of CD4+ T-Cells in Cancer Immunology
7. Role of Regulatory T-Cells and Th17 Cells in Tumor Microenvironment
8. Role of Monocytes, Macrophages, and Polymorphonuclear Cells in Cancer Immunology
9. Role of Cytokines in Cancer Immunology
10. Role of Chemokines and Chemokine Receptors in Cancer Immunology
11. Role of the Inflammasome in Cancer Immunology
12. Current Advanced Immunological Tools and Databases in Tumor Immunity
13. Tumor Heterogeneity and Therapeutic Resistance
Part B: Cancer Immunotherapy
14. Cancer Immunotherapy: Pros, Cons, and Beyond
15. Role of Monoclonal Antibody, Immune Checkpoint Inhibitors, and Programmed Death Ligand 1 in Cancer Immunotherapy
16. Role of Chimeric Antigen Receptor-T Cell in Cancer Immunotherapy
17. Role of Small Molecule-Based Drugs in Cancer Immunotherapy
18. Role of Adoptive Cell Therapy in Cancer Immunotherapy
19. Role of Cancer Vaccines in Cancer Immunotherapy
20. Role of Radiotherapy/Chemotherapy in Cancer Immunotherapy
