Full Description
Natural Product Drug Discovery: Highly Anticipated Natural Molecules provides a comprehensive examination of the role of natural products in innovative drug development. This research level reference addresses the significant challenges that highly active natural molecules face in the drug development process, including issues related to bioavailability and potency. The book presents detailed analyses of various classes of natural products, including polysaccharides, volatile oils, and diterpenoids, exploring their chemical properties, biological activities, and potential clinical applications. Each chapter is authored by leading experts in the field, offering insights into structural modification techniques, naturally sourced inhibitors, and the application of green biomanufacturing strategies to enhance drug development. This volume in the Drug Discovery Opinion series serves as an essential resource for researchers, pharmacologists, and industry professionals involved in natural product drug discovery. It provides the necessary information to navigate the complexities of this field, emphasizing the integration of traditional knowledge with modern scientific approaches. Through a thorough understanding of these natural compounds, this book aims to contribute to the advancement of therapeutic innovations in pharmacotherapy.
Contents
1. Highly Anticipated Natural Molecules
2. The Key Technology in Drug Discovery: Structural Modification of Natural Products
3. Naturally Sourced Sodium-Glucose Co-transporter 2 Inhibitors for Hypoglycemic: From Phlorizin to Dapagliflozin
4. Polysaccharides from TCM as an Important Resource of New Drugs for Antiosteoporosis and Neurodegenerative Diseases
5. Drug Discovery from Daphnane-type Diterpenoids: A Balance Between the Anti-HIV Effect and Toxicity
6. The Promising Future of Sesquiterpenoids: A Potential Source of New Drugs
7. Tussilagone as a Potential Therapeutic Candidate Against Inflammation-Related Diseases
8. Right Time for Drug Development from Volatile Oils
9. Natural Products in Alzheimer's Disease
10. The Discovery, Synthesis, and Bioactivities of Marine Sesquiterpene Hydroquinones/Quinones
11. Cardiac Glycoside: A Potential Antineoplastic Candidate from a Medication of Heart Failure and Atrial Arrhythmia
12. Natural Products as Potential Neuroprotective Agents for Ischemic Stroke
13. Key Strategy for Drug Development: Green Biomanufacturing of Active Natural Products
14. Research and Development of the Anti-Tumor Star Molecule Taxol
15. Bile Acids: Dual Facets as Modulators and Targets in Natural Product Drug Discovery
16. Natural Cephalotane Alkaloids from Cephalotaxaceae as a Source of New Anticancer Drugs
17. Computation-Enabled Natural Products Drug Discovery
18. Active Metabolites Derived from Microorganisms of Extreme Environments
