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Full Description
Neurogenetic Therapies: Advancements in Treating Nervous System Disorders offers a comprehensive resource on the latest gene therapy techniques and their applications in treating neurological disorders. This authoritative guide is designed to provide students, researchers, and clinicians with in-depth knowledge of innovative gene transfer technologies and their clinical implications. The book delves into various gene therapy methods, including genomic DNA-based therapies, vector-mediated delivery, and RNA interference-based gene silencing. It explores the use of these techniques in treating conditions such as Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, and Duchenne muscular dystrophy. Key topics include the molecular and genetic basis of nervous system disorders, the role of epigenetics, and the development of stem cell and genome editing therapies. With contributions from leading experts, the book also addresses regulatory and ethical considerations in gene therapy, providing a balanced perspective on the challenges and opportunities in this rapidly evolving field. Case studies and practical examples illustrate successful gene therapy treatments, offering valuable insights into translating research into clinical practice. This book is an essential resource for students, researchers, and scientists in neurogenetics, neurology, and molecular biology, as well as clinicians interested in the mechanisms and treatment of neurodegenerative diseases. It equips readers with the knowledge and tools needed to advance their work and drive innovation in neurogenetic therapies.
Contents
1. Molecular and Genetic Basis of Nervous System Disorders
2. Systems Biology Approaches in the Diagnosis of Neurological Disorders
3. Approaches for Gene Therapy and Its Possible Uses in Neurological Disorders
4. Genomic DNA-Based Gene Therapy: Recent Developments and Future Directions
5. Vector-Mediated Delivery of Transgenes and RNA Interference-Based Gene Silencing Sequences to Oligodendrocytes
6. Gene Transfer to Spinal Cord Neurons and Glial Cells through Adeno-Associated Virus Vector
7. Gene Therapy Models
8. Case Studies Based on Gene Therapies in Treating Neurological Disorders
9. Viral Gene Therapy Targets Astrocytes for Alzheimer's Disease
10. Lentiviral Gene Delivery of Orexin to Study Its Role in Alzheimer's Disease
11. Neurotrophin Gene Therapy for Parkinson's Disease Under Pharmacological Regulation
12. An Emerging Target for Parkinson's Disease Symptom and Medication Management: p11 Gene Therapy
13. Application of Gene Therapy Employing Stem Cells to Treat Neurological Disorders
14. Developing Human-Induced Pluripotent Stem Cells into Purkinje Neurons
15. Utilizing Herpes Simplex Virus Mutants as a Therapeutic Intervention for Neurogenic Pain
16. A Synopsis of Preclinical and Clinical Trials Concerning Immunotherapy Virotherapy for Astrocytoma
17. Nanoparticles in the Treatment of Neurological Disorders
18. Success Rates / Failures of Gene Therapy Techniques
