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Neurobiology of Depression: Road to Novel Therapeutics, Second Edition provides the latest research advances, including interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the novel optogenetic techniques revolutionizing depression research. This new edition aids advanced students and researchers in their understanding of MDD, presenting chapters that explore groundbreaking topics such as the neurobiology of treatment-resistant depression, the mechanisms that make ketamine a better antidepressant, and the link between depression and Alzheimer's disease. Additionally, it covers the neurobiology of suicide in depression, the impact of psychedelics as therapy, and the unique aspects of bipolar depression.
The book also examines computational models in depression, the neurobiology of psychotherapy, and the putative mechanisms of action for vagus nerve stimulation as a therapeutic approach. These additions help provide a broader and more comprehensive understanding of depression and its treatment.
Contents
1. The Classification of Depression: Embracing Phenotypic Heterogeneity in the Era of the RDoC
2. Incidence, Prevalence, and Global Burden of Depression
3. The Role of Environmental and Psychosocial Factors in Depression
4. Gene-Environment Interactions and Epigenetic Mechanisms in Depression
5. Pathophysiology of Cognitive Impairment in Depression
6. Anhedonia in Depression: Mechanisms, Assessment, and Therapeutics
7. The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic Implications
8. The Monoamine Hypothesis of Depression Revisited: Could It Lead to Mechanistically Novel Antidepressant Strategies?
9. Neuro-Immune Interactions in Depression: Mechanisms and Translational Implications
10. The Hypothalamic-Pituitary-Adrenal Axis in Depression: Molecular Regulation, Pathophysiological Role, and Translational Implications
11. Intracellular Signalling Pathways Implicated in the Pathophysiology of Depression
12. The Long-Lasting Neurobiological Scars of Early-Life Stress: Implications for the Neurobiology of Depression
13. Molecular, Cellular, and Circuit Basis of Depression Susceptibility and Resilience
14. More Than a Gut Feeling: Emerging Roles of the Microbiome in the Pathophysiology and Treatment of Depression
15. Optogenetics: Illuminating the Neural Circuits of Depression
16. Mitochondrial Dysfunction and Oxidative Stress: Relevance to the Pathophysiology and Treatment of Depression
17. Obesity and Depression: Shared Pathophysiology and Translational Implications
18. Neurobiology of Antidepressant-Induced Weight Gain
19. Depression and Cardiovascular Risk: Epidemiology, Mechanisms, and Implications
20. Poststroke Depression: Pathophysiology and Treatment Strategies
21. Is Depression Associated with Accelerated Aging? Mechanisms and Implications
22. Relationship Between Complicated Grief and Depression: Relevance, Etiological Mechanisms, and Implications
23. Understanding the Neurobiology of Depression through Structural Neuroimaging
24. A Neural Circuit-Based Model for Depression Anchored in a Synthesis of Insights from Functional Neuroimaging
25. Could Depression Be Preventable? Evidence and Perspectives
26. Treating Depression in the Era of Precision Medicine: Challenges and Perspectives
27. Neurobiological Aspects of Functional Recovery in Major Depressive Disorder
28. Diet and Depression: From Epidemiology to Novel Therapeutics
29. Physical Activity and Exercise as a Treatment of Depression: Evidence and Neurobiological Mechanism
30. Antidepressants and Suicidality—Controversies and Possible Mechanisms
31. Altered GABAergic Function, Cortical Microcircuitry, and Information Processing in Depression
32. Implications of Pharmacogenomics in Depression Pathophysiology and Treatment
33. Novel Neuromodulatory Approaches for Depression: Neurobiological Mechanisms
34. Electroconvulsive Therapy for Depression: Neurobiological Mechanisms
35. Putative Mechanism of Action for Vagus Nerve Stimulation as Therapeutic for Depression
36. Deep Brain Stimulation: Mechanisms Underpinning Antidepressant Effects
37. Novel Therapeutic Targets for Major Depressive Disorder
38. The Search for Rapid Acting Antidepressants: Research Synthesis and Perspectives
39. Neurobiology of Child and Adolescent Depression
40. Neurobiology of Depression in Women
41. Biological Basis of Late-Life Depression
42. Advances in Early Age Depression
43. What Makes Ketamine a Better Antidepressant?
44. Neurobiology of Suicide in Depression
45. Neurobiology of Depression as a Risk Factor for Alzheimer's Disease
46. Neurobiology of Treatment-Resistant Depression
47. Understanding the Mechanism of Action of Psychedelics as Therapy for Depression
48. Neurobiology of Bipolar Depression
49. Computational Models in Depression
50. Neurobiology of Psychotherapy for Depression
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