Full Description
Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Section I covers the technical aspects of troponin assays, comparing traditional and high-sensitivity assays, and exploring point-of-care testing advancements. It also examines age-related changes and intra- and inter-individual variability in troponin levels. Section II focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity. Section III discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice. Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis is an invaluable resource for researchers, clinicians, and healthcare professionals seeking to understand the impact of aging on troponin levels.
Contents
Section I. Pre-clinical: Technical aspects
1. Traditional Versus High-sensitivity Troponin Assays
2. Point-of-care Troponin Assays
3. Age-related Changes of Troponin
4. Intra-individual Variability in Troponin
5. Inter-individual Variability in Troponin
Section II. Clinical: Diagnosis
6. Troponin As a Biomarker of Cardiac Injury
7. Troponin As a Biomarker of Cardiac Dysfunction in Cancer Patients
8. Effects of Age on Diagnostic Sensitivity and Specificity of Troponin in Patients with Suspected Myocardial Infraction
9. Diagnosis of Acute Myocardial Infarction in Renal Impairment
10. Sex-specific Cut-offs for Diagnosing Myocardial Infarction for Different Age Groups
11. The Impact of Central and Peripheral Haemodynamics on Troponin Levels
Section III. Epidemiological: Prognosis and Model Development
12. Troponin and Age-related Cognitive Decline
13. Troponin and Age-related Renal Decline
14. Troponin As a Prognostic Marker of Mortality in Pulmonary and Heart Disease
15. Troponin in Sepsis
16. Troponin As a Prognostic Marker of Mortality in the General Population
17. Troponin in Acute and Chronic COVID-19 Infections
18. Population Differences in Troponin
19. Troponin As a Marker of Organ and Overall Biological Age
20. Novel Biomedical Engineering Considerations Using Nanosensing to Increase Sensitivity of Troponin Detection
21. Binding of DNA Aptamers to Troponin: Potential Clinical Uses
Section IV. Summary
22. Clinical Applicability: The Impact of Accelerated Diagnostic Protocols Incorporating High-sensitivity Troponin Assay in the Emergency Department
23. Clinical Applicability: Perspectives From the Physician
