Antimicrobial Therapeutics and Drug Discovery (Drug Discovery Opinions)

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Antimicrobial Therapeutics and Drug Discovery (Drug Discovery Opinions)

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  • 製本 Paperback:紙装版/ペーパーバック版／ページ数 600 p.
  • 言語 ENG
  • 商品コード 9780443365188

Full Description

Antimicrobial Therapeutics and Drug Discovery is a comprehensive resource that provides an overview of antimicrobial drug discovery. It covers a wide spectrum of pathogenic organisms causing human infections, exploring alternative therapeutic strategies beyond traditional small molecule drugs. The contents in the book are structured into four parts, each focusing on a different aspect of antimicrobial drug discovery. From exploring viral and host targets, understanding antibiotic resistance mechanisms, to the potential of nanomedicine and computational approaches, the book offers a comprehensive view of the field. Employing a multidisciplinary approach, chapters discuss the importance of drug discovery for fungi, Mycobacteria, Mycoplasma, and parasites, and offers insights into innovative biomedical approaches and combination therapies. By bridging the gap between experimental research and practical application, Antimicrobial Therapeutics and Drug Discovery is a key reference for pharmacologists and pharmaceutical scientists working in academic and corporate research. Medicinal chemists and microbiologists will also benefit from the multidisciplinary coverage of the book.

Contents

Part I: Antiviral Drug Discovery
1. Exploring Viral and Host Targets for Antiviral Drug Discovery
2. COVID-19 Challenges and its Therapeutics
3. From Lab to Clinic: The Evolution of Reverse Transcriptase Inhibitors in HIV Treatment
4. Targeting Hepatitis C Virus Polymerase: Non-Nucleoside Inhibitors (NNIs) and Drug Resistance
5. Challenges, Progress, and Prospects of Drug Discovery to Treat Chronic Hepatitis B (CHB) Infection
6. Discovery and Development of Antiviral Therapies for Influenza Virus Infections
7. Medicinal Chemistry Strategies for the Discovery and Development of Anti-Herpesvirus Drugs
8. Opportunities and Challenges in Targeted Protein Degradation for Antiviral Drug Discovery

Part II: Antibacterial Drug Discovery
9. Molecular Mechanisms of Antibiotic Resistance
10. Overview of the Antibiotics Approved in the Last Two Decades: Retrospect and Prospect
11. Antibiotic Resistance Breakers: Current Approaches and Future Directions
12. Innovative Approaches in Developing Antimicrobial Peptides for Drug-Resistant Bacterial Infections
13. The Potential of Antibody-Antibiotic Conjugates in Combatting Bacterial Diseases
14. Phage Therapy: Current Advancements and Future Prospects in Combating Antimicrobial Resistance

Part III: Drug Discovery for Miscellaneous Pathogens
15. Antifungal Drug Resistance: Current Mechanisms and Future Directions
16. Challenges, Unmet Clinical Needs, and Novel Approaches in the Discovery of Antifungal Drugs
17. Drug Discovery against Mycobacteria: The Success and Challenges
18. Future of Drug Development for the Treatment of Mycoplasma Infections
19. Antimalarial Drug Discovery: From Novel Molecules to Clinical Development

Part IV: Next-Generation Antimicrobial Strategies
20. Computational Approaches in Antimicrobial Drug Discovery
21. Multi-Omics Approaches for Antimicrobial Drug Discovery
22. Nanomedicine as a Next-Generation Antimicrobial Therapy: New Frontiers in Fighting Microbial Infections
23. Drug Repurposing: Innovative Antimicrobial Strategies to Combat Resistance
24. Drug Combinations: A Strategy to Extend the Life of Antimicrobials
25. Ethical Imperatives in Combating Antimicrobial Resistance: A Global Perspective