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Full Description
Unlocking the secrets of extracellular vesicles and exosomes: A journey into the cutting-edge frontier of cellular communication provides a comprehensive overview of the latest advances and research on extracellular vesicles (EVs) and exosomes. The book begins with a historical introduction to the field and how this has evolved since EVs were first observed, before exploring their cellular mechanisms and approaches to study their isolation, characterization, and function. It then delves into exosomes in health and disease, considering their role across cancer, regenerative medicine, neurological disorders, and metabolic disorders, highlighting their potential as biomarkers for disease diagnosis. The book moves on to discuss cutting-edge technology for the engineering of EVs and exosomes, considering how the integration of AI, machine learning, and nanotechnology can be utilized to expand the therapeutic capabilities of EV and exosome-based applications. It then closes with chapters covering novel applications in nutraceutical and cosmetic production, and a look towards the future potential of EVs and exosomes. Unlocking the secrets of extracellular vesicles and exosomes offer a thorough exploration of EV and exosome research, covering various dimensions from basic science to clinical applications and future perspectives. It is an ideal guide for researchers working across a diverse range of disciplines, including cell biology, molecular biology, biotechnology, therapeutics, and biomedicine.
Contents
Section 1 Extracellular vesicles/exosomes as novel sources of cellular communication
1. Historical context and the evolution of exosome research
2. The cellular machinery behind exosome formation
3. Exosomes as messengers: intercellular communication
4. Exosomes: essential messengers in intercellular communication
5. Exosomes as cellular couriers: the mechanisms of intercellular messaging
Section 2 Extracellular vesicles/exosomes: methods and protocols
6. Comprehensive approaches to isolation, characterization, and functional assessment of extracellular vesicles
Section 3 Extracellular vesicles/exosomes in health and diseases: Potential applications
7. Exosomes as biomarkers for disease diagnosis
8. The intricate interplay between cancer cells and exosomes
9. Advancements in stem cell therapy facilitated by exosomes
10. Crossing the blood-brain barrier: exosomes in neurological research
11. Exosomes as vectors across the blood-brain barrier in neurological research
12. Unraveling the role of exosomes in modulating immune responses
13. The immunological impact of exosomes: modulation and mechanisms
14. Exploring the link between exosomes and metabolic diseases
15. Role of exosomal microRNAs in anticancer drug resistance and tumor angiogenesis
16. Health implications of retinoic acid in exosome biogenesis, secretion, and uptake
17. Exosomes in aging and longevity
Section 4 Engineering and scaling up extracellular vesicles and exosomes production: Medicine, nutraceuticals, cosmetics, and novel applications
18. Cutting-edge technology for extracellular vesicles and exosomes production: future prospects
19. Novel application of extracellular vesicles and exosomes in nutraceutical and cosmetic production
20. Ethical considerations, challenges, and the road ahead: exosomes in the next decade
