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Full Description
The Neurological and Immunological Basis of Itch and Dermatological Disorders covers the latest research on neurological itch signaling pathway from the skin to the brain. With a multidisciplinary approach, this book will cover the mechanisms underlying the sensation of itch from the fields of neuroscience, immunology, genetics, and dermatology as they have intersected in the study of one somatosensory system. The purpose of this comprehensive reference is the summarize the revelatory discoveries in the field of itch and provide a comprehensive overview of what is known about this remarkable sensation and how various pathologies contribute to chronic pruritis.
Contents
Section 1 Preclinical Perspective
1. Historical perspective
2. Receptors of itch (also types of itch: histaminergic and non histaminergic itch)
3. TRP channels
4. Mast cells and itch
5. Mucosal Itch
6. Neuroimmune interactions in itch
7. Mouse models for itch
8. Itch sensitization (models for chronic itch in the mouse)
9. Bacteria induced itch
10. Primary Afferent neurons
11. Spinal pathways and projection neurons
12. Central Targets for Itch
13. Cortical processing of itch
14. Descending Modulation of itch
15. Mechanical Itch and Alloknesis
16. Neural coding of itch versus pain
17. Drugs which induce itch (including opioids)
18. Glia neuron interactions in the spinal cord
19. Cytokine in itch induction and modulation
Section 2: Clinical Perspectives
20. Itch Fibers in humans
21. Atopic Dermatitis
22. Psoriasis
23. Prurigo nodularis
24. Cholestatic itch (Liver disease)
25. Neuropathic itch
26. fMRI and Itch
27. Recent advances for drug targets to treat itch
