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Full Description
The Itch Spectrum: The Neurological and Immunological Basis of Itch and Dermatological Disorders covers the latest research on the itch signalling pathway from the skin to the brain. With a multidisciplinary approach, this book will cover the mechanisms underlying the sensation of itch from the fields of neuroscience, immunology, genetics, and dermatology as they have intersected in the study of one somatosensory system. The purpose of this comprehensive reference is to summarize the revelatory discoveries in the field of itch and provide a comprehensive overview of what is known about this remarkable sensation and how various pathologies contribute to chronic pruritis.
Contents
Section 1: Preclinical Perspective
1. Historical perspective of itch research
2. Primary afferent neurons involved with itch
3. Receptors of itch: GPCRs
4. TRP channels for itch
5. Ion channels for itch
6. Neuroimmune interactions in itch
7. Cytokine in itch induction and modulation
8. Mast cells and itch
9. Bacteria and Virus Induced itch
10. Spinal pathways and projection neurons for itch
11. Spinal Glia-Neuron interactions in chronic itch
12. Central targets for itch
13. Aversive and reward circuits in itch processing
14. Descending modulation of itch
15. Neural coding of itch versus pain
16. Mechanical itch and alloknesis
17. Mouse models for acute itch
18. Mouse models of chronic itch
19. Mucosal itch
20. Drug induced itch
21. Conservation of itch across species
Section 2: Clinical Perspectives
22. Epidemiology of itch
23. Atopic dermatitis
24. Psoriasis
25. Prurigo nodularis
26. Cholestatic and uremic itch
27. Neuropathic itch
28. Itch caused by connective tissue diseases
29. fMRI and itch
30. Recent advances for drug targets to treat itch
