Membrane Transporters and Drug Delivery : A Comprehensive and Multidisciplinary Guide

Puris, Elena (EDT)/ Fricker, Gert (EDT)/ Terasaki, Tetsuya (EDT)

Academic Press Inc（2026/08発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 400 p.
• 言語 ENG
• 商品コード 9780443337833

Full Description

Membrane Transporters and Drug Delivery: A Comprehensive and Multidisciplinary Guide is a comprehensive reference on the rapidly evolving field of membrane transporters and their role in drug delivery. This book is designed to serve pharmaceutical researchers both academia and industry, providing in-depth coverage of all aspects of transporter-related drug delivery research. The book begins with a comprehensive introduction to membrane transporters, their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery. A unique feature of this book is its detailed exploration of the methodologies used in transporter research, providing readers with a comprehensive understanding of the strengths and limitations of each approach. It examines the roles of both efflux and influx transporters in drug pharmacokinetics and covers different strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types. The book concludes with a discussion on regulatory and industrial aspects of transporter-related projects and explores the potential of artificial intelligence in transporter and drug delivery research. It also offers a glimpse into future challenges and perspectives in this field. Membrane Transporters and Drug Delivery: A Comprehensive and Multidisciplinary Guide is an essential resource for anyone involved in drug development projects utilizing transporter-mediated drug delivery or targeting. It is a must-have for those seeking to design successful drug development projects and stay at the forefront of this rapidly developing field.

Contents

Part I - Basic concepts of membrane transporters
1. Introduction to membrane transporters and drug delivery
2. Structure and mechanism of membrane transporters
3. Regulation of membrane transporters

Part II - Transporters in drug disposition
4. Role of transporters in drug disposition and its clinical significance
5. Transporter-mediated drug-drug interactions

Part III - Transporters in diseases
6. Cancer
7. CNS diseases
8. Liver
9. Kidney
10. Ocular diseases

Part IV - ABC transporters in drug delivery
11.Role in drug delivery
12. Strategies for drug delivery

Part V - SLC transporters in drug delivery
13. Role in drug delivery
14. Strategies for drug delivery

Part VI - Methods for investigating transporter-mediated drug delivery
15. In vitro and ex vivo methods
16. In vivo studies
17. In silico approaches
18. Physiologically based pharmacokinetic modelling
19. Pharmacoproteomics
20. Pharmacogenomics
21. Human studies

Part VII - Conclusions and Perspectives
22. Regulatory and industrial aspects
23. The use of artificial intelligence in transporter research
24. Final remarks and future directions of the field