Full Description
Ligands for Targeted Drug Delivery: Basic Fundamentals and Applications is a comprehensive reference focused on the many ways drug carriers can be functionalized to target specific organs, tissues, cells, and sub-cellular compartments. Chapters cover the basic concepts of targeted drug delivery, describing multiple levels of targets and challenges, along with approaches for target-specific drug delivery and a thorough overview of the challenges in design and application of ligands. Following sections discuss nanoparticles and the main ligand classes with their respective applications. The final chapters discuss future prospects of the technology and clinical aspects of ligand modified drug delivery systems.
This is a key reference to drug delivery researchers dealing with the application of ligands to overcome challenges in delivering their active principles to the target structure. Biomedical engineers, materials scientists, and chemists can also benefit from the through description of ligand classes and their potential to improve drug delivery efficiency.
Contents
1. Basic concepts and Levels of Drug Targeting
2. Ligand based approaches for target-specific drug delivery
3. Challenges in design of ligand-targeted drug delivery systems
4. Ligand conjugation strategies
5. Aptamers as ligand and Applications in Drug Delivery
6. Sugar as ligand and Applications in Drug Delivery
7. Proteins, peptides and its derivatives as Ligand and Applications in Drug Delivery
8. Biological ligands and Applications in Drug Delivery
9. Polymers as ligand and Applications in Drug Delivery
10. Approaches for tight junction opening
11. Future Prospects of Targeted Drug Delivery
12. Clinical aspects of ligand modified drug delivery systems
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