Full Description
Diabetes and Neurodegeneration unlocks the complex interplay between diabetes and Neurodegeneration, reviewing the relationship between these two prevalent health challenges. This book begins with a simple guide to understanding high blood sugar, tracing the historical milestones of hyperglycemia, and unveiling the primary factors that contribute to diabetes development, from genetic predisposition to lifestyle hazards. The second section aims to bridge the gap between diabetes and dementia, presenting early clinical evidence, case studies, and susceptibility assessments that underscore the strong link between hyperglycemia and neurodegeneration. Biomarkers and pathways connecting these conditions are explored, including the role of Advanced Glycated End (AGE) products and their implications in protein misfolding and aggregation. The narrative extends to therapeutic strategies, evaluating the efficacy of antidiabetic drugs, targeting insulin resistance, and introducing novel interventions to arrest amyloid-associated pathogenesis. This comprehensive guide provides both clinicians and researchers with a thorough understanding of the intricate link between diabetes and neurodegeneration.
Contents
INTRODUCTION: PATHOGENESIS OF DIABETES AND DEMENTIA
1. Why and when does one have high blood sugar?
2. The History of hyperglycemia: key milestones in the inception of the disease in human health
3. Neurodegeneration: How to identify the primary symptoms of cognitive impairment
4. Direct consequences of diabetes over the nervous system: Structural and electrophysiological changes
DISCOVERING THE BRIDGE BETWEEN DIABETES AND DEMENTIA
5. Early Clinical Evidence that suggest a strong link between Hyperglycemia and onset of neurodegeneration
6. Case studies for a systematic understanding of development of dementia in diabetic or pre-diabetic patients
7. Susceptibility assessment of dementia in diabetic or prediabetic conditions
8. Metabolic connections between Diabetes and AD
9. Role of diabetes and altered metabolic homeostasis in age related dementia
10. Oxidative stress in brain accelerates the onset of neurodegeneration in hyperglycemic individuals
11. Cardiovascular diseases in diabetic individuals aggravate the propensity of dementia
12. Disruption of insulin signaling causes major cognitive impairment
BIOMARKERS AND PATHWAYS WHICH CONNECT DIABETES AND DEMENTIA
13. Early diagnostic and prognostic biomarkers of diabetes and cognitive impairment
14. Periphery biomarkers to assess the vulnerability of Type 2 diabetic patients to AD
15. Advanced Glycated End (AGE) Product: the most significant metabolic by-product implicated in dementia
16. The Physiological role of AGE: RAGE axis in the body: Implications in cellular defense
17. Role of AGE molecules in protein misfolding and aggregation
18. AGE molecules as major culprits behind amyloidogenic protein aggregation
19. Shared pathways of Type 2 diabetes and Alzheimer's Disease
20. Role of gut microbial amyloids in progressive cognitive decline
21. Exploring the unknown territory of Gut: Brain axis in diabetic patients: impact of elevated blood sugar on microbial amyloids
THERAPEUTIC STRATEGIES TO ARREST AND/OR DELINK DIABETES AND DEMENTIA
22. Evaluation of efficacy of antidiabetic drugs to arrest dementia
23. Targeting Insulin resistance to treat cognitive impairment
24. RAGE based therapeutic interventions: Do they aggravate or ameliorate dementia?
25. Soluble form of RAGE (sRAGE) receptors as novel therapeutic intervention to arrest amyloid associated pathogenesis
26. Assessing the efficacy of antidiabetic phytotherapeutic interventions towards improvement of cognitive functions
FUTURE FRONTIERS IN DIABETES AND DEMENTIA
27. Commentary: Diabetes and cognitive health: How can we save the future generation
