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Full Description
Nerve growth factor: From neuron development to neurology offers a complete guide to nerve growth factor (NGF) across health and disease. It provides a well-rounded discussion of NGF and the key properties, latest advances, and biomedical applications of this neuropeptide. The book begins with an introduction and historical overview of the discovery of NGF before exploring its molecular characteristics. It then covers NGF in organ function, with chapters ranging across the brain, immune system, blood vessels, heart, reproductive organs, teeth and lungs. NGF pharmacology is then considered in detail, with a focus on NGF as a therapeutic agent. The final section of the book covers NGF across disease, which includes Alzheimer's disease, cancer, diseases of the eye, chronic pain and visceral disfunctions. Throughout the book, NGF is considered in the context of both mammalian and non-mammalian biology. Nerve growth factor: From neuron development to neurology is the latest volume in the Elsevier book series Molecular Mediators in Health and Disease, and is an ideal reference for researchers working across the fields of cell biology, molecular biology, pharmacology and other biomedical areas.
Contents
Part I - Introduction to Nerve Growth
1. History of Nerve Growth
2. Nerve Growth Factor in Normal Biology
Part II - Molecular biology of Nerve Growth
3. Production and structure of Nerve Growth
4. Measurement of Nerve Growth Factor and its precursor
5. Nerve Growth Factor receptors
Part III - Nerve Growth Factor in organ function
6. NGF in sensory and sympathetic neurons
7. NGF in Brain
8. NGF and the immune system
9. NGF in blood vessels and heart
10. NGF in reproductive organs
11. NGF in teeth
12. Nerve Growth Factor and the Lung.
Part IV - Nerve Growth Factor pharmacology
13. TrkA mimetics
14. P75NTR receptor blockers
15. Antibodies neutralizing NGF or TrkA
16. Nerve Growth Factor protein as a therapeutic agent
Part V - NGF in non-mammalian biology
17. NGF in non-mammalian organisms
Part VI - Nerve Growth Factor in Disease
18. Nerve Growth Factor and Alzheimer's disease
19. Nerve Growth Factor and diseases of the eye
20. Nerve Growth factor and cancer
21. Nerve Growth Factor and chronic pain
22. Nerve Growth Factor and visceral disfunctions



