Full Description
Endotoxin in Critical Illness intricately explores the theme of endotoxin and sepsis through the lenses of basic, clinical, and translational science. This work consolidates and synthesizes novel clinical insights and groundbreaking scientific discoveries into one comprehensive resource on endotoxic septic shock and sheds light on cutting-edge approaches in treatment. Beginning with a historical journey, the book traces the evolution of understanding from ancient concepts to modern molecular insights. It covers the physiological aspects of endotoxin sensitivity, tolerance, and human response variation. The crucial role of the gut microbiome in critical illness serves as a translational link between foundational science and clinical implications, and the complex language of bacterial communication is introduced, merging basic science with potential translational applications. In the clinical arena, chapters cover the critical role of endotoxin in septic shock, trauma, and its relevance in COVID-19, providing a translational bridge between laboratory findings and real-world clinical scenarios. The historical context of anti-endotoxin drug development is revisited, emphasizing the translational challenges faced in bridging basic science discoveries to clinical applications. The discussion on quantifying endotoxin concentration as well as the exploration of therapeutic rationale and clinical experiences with endotoxin removal therapy serve as a culmination of basic understanding translated into practical applications. The book concludes by contemplating the complexity of sepsis and acknowledging the challenges in achieving personalized medicine and underscoring the dynamic nature of the translational journey. In essence, this comprehensive exploration provides clinicians, researchers, and scientists with a holistic understanding of endotoxin and sepsis and potential advancements in patient care.
Contents
1. Sepsis and Endotoxin: a brief history
2. Endotoxin signaling: the TLR4 pathway and alternates
3. Endotoxin physiology
4. Origins of human sensitivity to endotoxin
5. Human variation in response to endotoxin
6. Gut microbiome and its effect on critical illness
7. Quorum sensing and its importance in bacteria
8. Quantifying endotoxin concentration in the blood/plasma/serum of humans, direct and indirect methods
9. Endotoxic in septic shock
10. Trauma and endotoxin
11. Endotoxemia in Covid-19
12. Anti-endotoxin drug development. Why did everything fail?
13. Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock
14. Clinical experience with PMX
15. Personalized medicine for sepsis. A dream or a reality?
