Full Description
Capsaicin, the Pungent Principle in Hot Pepper: From Basic Pharmacology to Therapeutic Applications explores capsaicin's biological and pharmacological characteristics, from its discovery and isolation to its receptor identification and antagonists. The book's structure is divided into three sections, starting with the historical development of research on capsaicin. This foundational section provides a thorough understanding of the compound's journey from a simple pungent ingredient to a significant element in pharmacological studies. The second part of the book delves into capsaicin's biological effects and pharmacology, covering areas such as nociception, pain, salivary secretion, body temperature regulation, and blood pressure regulation.
Finally, the book examines the clinical applications of capsaicin, discussing potential future developments in desensitization, pain relief, injections, effects on the tumor microenvironment, appetite control, and longevity. This book is invaluable for pharmacology researchers and clinicians in pain management and cancer, offering insights into the unique characteristics and therapeutic potential of capsaicin.
Contents
SECTION 1: CAPSAICIN AND ITS RECEPTOR: HISTORY, CHEMISTRY AND BIOLOGICAL BACKGROUND
1. A brief history of capsaicin (hot pepper)
2. The hunt for the capsaicin receptor
3. The discovery of Resiniferatoxin
4. Breakthrough: molecular cloning of the capsaicin receptor TRPV1 in 1997
5. Brain TRPV1: a controversial topic.
6. TRPV1 antagonists
SECTION 2: THE BIOLOGICAL EFFECTS AND PHARMACOLOGY OF CAPSAICIN
7. The pharmacology of capsaicin I - Nociception and Pain
8. The pharmacology of capsaicin II - Salivary secretion
9. The pharmacology of capsaicin III - Body temperature regulation.
10. The pharmacology of capsaicin IV - Capsaicin and blood pressure regulation.
11. Capsaicin analogues
SECTION 3: CURRENT AND PERSPECTIVE USE OF CAPSAICIN IN CLINICAL SETTINGS
12. Capsaicin desensitization
13. High-dose capsaicin path for pain relief.
14. Site-specific capsaicin injections for pain relief.
15. Intravesical capsaicin for detrusor hyperreflexia.
16. Capsaicin-sensitive afferents in the tumor microenvironment.
17. Dietary capsaicin: appetite control, obesity.
18. Capsaicin for longevity
19. Concluding remarks
