Full Description
Navigating Tuberculosis: Insights into Host-Pathogen Protein Interactions explores the intricate interactions between host proteins and the tuberculosis pathogen, Mycobacterium tuberculosis (M. tb), emphasizing their roles in virulence and pathogenesis. This comprehensive volume aims to advance knowledge and strategies to combat tuberculosis, aligning with the World Health Organization's goal of eradicating TB by 2035. The book delves into the mechanistic insights of host and TB pathogen proteins, focusing on their roles in modulating innate and adaptive immunity. It enhances the understanding of TB pathomechanisms by elucidating the interplay between host defenses and M. tb infection, providing a foundation for developing targeted strategies to mitigate tuberculosis. Key regulatory pathways and protein factors involved in host-pathogen interactions are explored, informing the design and implementation of innovative approaches to combat TB effectively. This book addresses the need for up-to-date information on host-pathogen interactions in tuberculosis, incorporating the latest research findings and advancements. It highlights emerging therapeutic targets among host and TB pathogen proteins and integrates multidisciplinary approaches from microbiology, immunology, and molecular biology, offering a holistic perspective on TB pathophysiology. Researchers will find detailed discussions on key host proteins involved in tuberculosis pathogenesis, the molecular tactics employed by M. tb to subvert host defenses, and host-mediated inhibition strategies targeting M. tb. The book provides a comprehensive framework for understanding M. tb pathophysiology and disease-causing mechanisms, laying the groundwork for proposing new host-directed therapies and host-pathogen interface-targeting therapies. This volume in the series Foundations and Frontiers in Enzymology is an essential resource for basic research scientists and researchers in microbiology, immunology, molecular biology, and infectious diseases. It equips them with the knowledge necessary to design better mitigation strategies against tuberculosis, fostering interdisciplinary collaborations and advancing the field of TB research.
Contents
1. Mechanisms of Mycobacterium tuberculosis Virulence: The esx1 Locus and Host Countermeasures
2. Host Adaptation Strategies of Mycobacterium tuberculosis: A Molecular Perspective
3. Unravelling M. tuberculosis Manipulation of Host Immunity: Insights from Functional Genomics and Proteomics
4. Macrophages: Frontline Warriors Against Mycobacterium tuberculosis Invasion
5. Unravelling Mycobacterium tuberculosis Pathogenesis: Insights into PE/PPE Proteins from a Molecular Viewpoint
6. Host-Pathogen Dynamics in Mycobacterium tuberculosis: The Impact of PE/PPE Proteins on Innate and Adaptive Immunity
7. PE/PPE Proteins in Mycobacterium tuberculosis: Key Regulators of Apoptosis and Pathogenic Outcomes
8. Autophagy and Mycobacterium tuberculosis: Host Defense Mechanisms Versus Pathogen Evasion
9. Mechanisms of Phagosomal Damage Detection and Response to Mycobacterium tuberculosis: Repair, Autophagy, and Biogenesis
10. Programmed Cell Death During Mycobacterium tuberculosis Infection: The Roles of Pyroptosis and Necroptosis in Host Defense
11. Metabolic Repurposing in Mycobacterium-Infected Macrophages: A Strategy for Enhanced Virulence and Survival
12. Type I Interferons in Tuberculosis: Friend or Foe?
13. Type II Interferon in Tuberculosis: Orchestrating Infection Outcome through Mechanistic Insights
14. Cell Envelope Dynamics in Mycobacterium tuberculosis: Implications for Tuberculosis Pathogenesis and Host-Pathogen Interaction
15. Combatting Tuberculosis Drug Resistance: Effective Strategies for Overcoming Challenges
16. Beyond Treatment: Strategies for Mitigating Long-Term Morbidity and Mortality in Tuberculosis Survivors
