Full Description
The Dual Role of Inflammation in Cancer Genesis and Therapy explores the pivotal role inflammation plays in the development and progression of cancer. The book delves into how chronic inflammation creates a microenvironment that supports tumor growth by promoting cellular proliferation, survival, and migration while suppressing immune responses. It traces historical observations, linking inflammation to cancer while also examining how inflammatory cells and mediators contribute to various stages of tumorigenesis. In addition, it discusses the implications of inflammation on cancer treatment, highlighting the potential of anti-inflammatory agents and immunotherapy in targeting the inflammatory tumor microenvironment.
By elucidating on the intricate relationship between inflammation and cancer, the book aims to pave the way for more effective and personalized cancer treatment strategies. As such, it is a valuable resource for researchers in immunology and oncology.
Contents
1. Introduction to Inflammation and Cancer
2. Chronic Inflammation and Cancer: Epidemiological Evidence
3. Role of Inflammatory Cells in Cancer Development
4. The Tumor Microenvironment and Inflammation
5. Cytokines and Chemokines in Tumorigenesis and Their Pro-tumorigenic and Anti-tumorigenic Roles in Cancer Development
6. The Role of Oxidative Stress in Inflammation-Mediated Cancer Progression Inflammation and Metastasis
7. Genetic and Epigenetic Changes Driven by Inflammation
8. Epigenetic Signaling: Regulation of Inflammation in Cancer
9. Inflammation and Tumor Progression: Signaling Pathways
10. Biomarkers and Signaling Pathways of Inflammation-Mediated Cancer Development: Promising Targets to Limit
11. Metastatic Potential and Stemness
12. Anti-inflammatory Agents in Cancer Prevention and Therapy
13. Tumor-Infiltrating Inflammatory Cells as Possible Therapeutic Targets
14. The Inflammatory Chemokines and in Malignancy: Leukocyte Migration and Beyond
15. Inflammation and Beyond: Complex Roles for TGF-β in the Tumor Microenvironment
16. Microenvironmental Mediators as Therapeutic Targets in Malignancy
17. Role of Macrophages in Regulating Tumor Angiogenesis: Implications for Cancer Therapy
18.Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy
19. Immunotherapy and Inflammation
20.Case Studies: Inflammation-targeted Cancer Therapies
21. Microbiota, Inflammation and Colorectal Cancer
22. Genomics and Microbiome and Their Immunotherapy Implications in Cancer
23. Modulation of Tumor Immunogenicity
24. Biomarkers Associated with Immunotherapeutic Response in Cancer
25. Endoscopy and AI in the Diagnosis and Early Detection of Dysplastic Lesions
26. Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction
27.Combinational Immunotherapy Against Cancer
28. Policy Recommendations Regarding Immunotherapy and Other Cancer Therapy
