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Full Description
Protein Kinase Inhibitors: The Promise of Natural Products in Cancer Therapeutics explores a novel therapeutic avenue for cancer treatment through nutraceutical-based kinase inhibitors. This comprehensive resource delves into the scientific mechanisms by which natural products influence kinase activity and disrupt cancer progression, providing valuable insights for researchers, healthcare professionals, and students alike. This book covers the historical background and modern outlook on nutraceuticals, their mechanistic pathways, and clinical aspects of natural CDK inhibitors, highlighting their relevance in cancer therapy. It also examines the potential of polyphenolic derivatives and other natural compounds in inhibiting key kinases involved in major cancer signaling pathways, focusing on their direct application in clinical trials and marketed drugs. Readers will explore topics such as the implications of polyphenols in cancer management, novel sources of breast cancer inhibitors, the role of natural products in lymphoma therapy, and the multitarget potential of phytochemicals. Each chapter is designed to provide a thorough understanding of how natural products can be harnessed to develop innovative cancer therapeutics. This book serves as a valuable resource for academics, scientists, young researchers, students, and pharmacists working or interested in kinase biology and cancer therapeutics. It offers a unique perspective on using nature's own arsenal to combat cancer, bridging the gap between scientific discovery and clinical application, and paving the way for future innovations in structure-based drug design.
Contents
1. Nutraceuticals: From History to Modern Outlook
2. Implications of Polyphenols in Cancer Management
3. Revealing Novel Sources of Breast Cancer Inhibitors
4. A Promising Natural Product in Diffuse Large B-Cell Lymphoma Therapy
5. Inhibiting Inflammation via IL-17/NF-κB Pathway
6. Mechanistic Pathways and Clinical Aspects of Natural CDK Inhibitors on Cancer Progression
7. Natural Kinase Inhibitors in Lymphoma Therapy
8. Natural Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma
9. Identification of Marine Natural Products as STAT3 Inhibitors for Efficient Anticancer Therapy
10. Multitarget Potential of Phytochemicals
11. Naturally Occurring Compounds as Potential Inhibitors of Epidermal Growth Factor Receptors
12. Exploring Potential Phytochemicals for Hepatocellular Carcinoma
13. The Natural Product in Resistant Lung Cancer
14. Anticancer Potential of Novel Natural Product Derivatives Targeting the PI3K/AKT Signaling Pathway
15. Plant-Based mTOR Inhibitors for Cancer Therapy
16. Role of Nutraceuticals in Combating Oxidative Stress via Modulating MAPK Signalling
17. Epigenetic Effects of SCFAs: Butyrate's Effects on Spleen Tyrosine Kinase (Syk) in Tumor Progression
18. Exploring Chemopreventive Effects of Olive Products Attenuating Cancer Signaling
19. Confronting Overexpressed Tyrosine Kinases with Curcumin: Advancing Adjuvant Cancer Therapies
20. Medicinal Benefits of Polyphenols in Cancer Prevention and Therapy through Suppression of PI3K Pathway
21. Structural Biology-Based Design of Selective Protein Kinase Inhibitors
22. Identifying Novel Cyclin-Dependent Kinase Attenuators Based on High Throughput Screening
23. Exploring the Potential of Pseudosaccharine Derivatives as Anti-Proliferative Agents and Kinase Inhibitors
24. Integrating Structure-Based Modeling and Advanced MD Simulation Strategy in Revealing the Potency of Natural Products as Dual Kinase Inhibitors
25. Discovering Novel Kinase Inhibitors: Moving from Structure to Clinical Leads
