Protein Kinase Inhibitors : The Promise of Natural Products in Cancer Therapeutics

Hassan, Md. Imtaiyaz (EDT)/ Noor, Saba (EDT)

Academic Press Inc（2026/04発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 500 p.
• 言語 ENG
• 商品コード 9780443275449

Full Description

Protein Kinase Inhibitors: The Promise of Natural Products in Cancer Therapeutics offers an in-depth exploration of how nutraceutical-based kinase inhibitors are shaping the future of cancer treatment. The book presents the scientific principles behind the ability of natural products to influence kinase activity, disrupt cancer progression, and open new avenues for therapeutic intervention. Covering both historical context and modern advances, it provides readers—ranging from researchers and healthcare professionals to students—with a comprehensive understanding of the mechanisms and clinical relevance of natural CDK inhibitors, emphasizing their growing significance in oncology.

The book also highlights polyphenolic derivatives and other natural compounds that target key kinases in major cancer signaling pathways. It features insights into topics such as polyphenols' roles in cancer management, new sources of breast cancer inhibitors, and natural products in lymphoma therapy. With chapters dedicated to the multitarget potential of phytochemicals and practical applications in clinical trials, this resource bridges scientific research and clinical practice, inspiring innovation in structure-based drug design and advancing the use of nature-derived therapeutics in cancer care.

Contents

1. Nutraceuticals: From History to Modern Outlook
2. Implications of Polyphenols in Cancer Management
3. Revealing Novel Sources of Breast Cancer Inhibitors
4. A Promising Natural Product in Diffuse Large B-Cell Lymphoma Therapy
5. Inhibiting Inflammation via IL-17/NF-κB Pathway
6. Mechanistic Pathways and Clinical Aspects of Natural CDK Inhibitors on Cancer Progression
7. Natural Kinase Inhibitors in Lymphoma Therapy
8. Natural Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma
9. Identification of Marine Natural Products as STAT3 Inhibitors for Efficient Anticancer Therapy
10. Multitarget Potential of Phytochemicals
11. Naturally Occurring Compounds as Potential Inhibitors of Epidermal Growth Factor Receptors
12. Exploring Potential Phytochemicals for Hepatocellular Carcinoma
13. The Natural Product in Resistant Lung Cancer
14. Anticancer Potential of Novel Natural Product Derivatives Targeting the PI3K/AKT Signaling Pathway
15. Plant-Based mTOR Inhibitors for Cancer Therapy
16. Role of Nutraceuticals in Combating Oxidative Stress via Modulating MAPK Signalling
17. Epigenetic Effects of SCFAs: Butyrate's Effects on Spleen Tyrosine Kinase (Syk) in Tumor Progression
18. Exploring Chemopreventive Effects of Olive Products Attenuating Cancer Signaling
19. Confronting Overexpressed Tyrosine Kinases with Curcumin: Advancing Adjuvant Cancer Therapies
20. Medicinal Benefits of Polyphenols in Cancer Prevention and Therapy through Suppression of PI3K Pathway
21. Structural Biology-Based Design of Selective Protein Kinase Inhibitors
22. Identifying Novel Cyclin-Dependent Kinase Attenuators Based on High Throughput Screening
23. Exploring the Potential of Pseudosaccharine Derivatives as Anti-Proliferative Agents and Kinase Inhibitors
24. Integrating Structure-Based Modeling and Advanced MD Simulation Strategy in Revealing the Potency of Natural Products as Dual Kinase Inhibitors
25. Discovering Novel Kinase Inhibitors: Moving from Structure to Clinical Leads