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Full Description
Kratom: History, Science and Therapeutic Potential is the first book to address the unregulated, widespread availability of kratom, with its weak opioid and stimulant effects, coupled with limited awareness of it by healthcare professionals. Kratom has great therapeutic utility and medicinal potential, but more study, caution, and possible regulation is needed. It discusses geographical sourcing, historical uses, current worldwide uses, and potential for treatment of other medical conditions. Most exciting for healthcare professionals will be the implications of this substance's potential for treatment of diseases like depression, ADHD, PTSD, and substance-use disorder, particularly opioid use disorder (OUD).
Moreover, kratom and its active alkaloid mitragynine are getting remarkable attention at federal and local governments as more than eight million Americans consume this product annually. Yet, the paucity of information for researchers and clinicians is troublesome.
Contents
Section 1: Background
1. Botany, geographical distribution, and phytochemistry of Mitragyna speciosa (Korth.) and related species
Satya Swathi Nadakuduti, Mengzi Zhang, Larissa C. Laforest and Brian Pearson
2. The scientific evolution of kratom: a historical overview
Thiruventhan Karunakaran, Yathindra Marimuthu, Balasingam Vicknasingam and Marek C. Chawarski
3. Recent patterns and reasons for use
Marc T. Swogger, Kirsten E. Smith, Tianna Torrice and Oliver Grundmann
Section 2: Basic science
4. Chemistry and metabolites: ADME
Manoj Gundeti, Christopher R. Mccurdy and Abhisheak Sharma
Section 3: Current therapeutic uses
5. Kratom-related physical dependence and addiction
Kirsten E. Smith, Darshan Singh and Oliver Grundmann
6. Current therapeutic uses
Norsyifa Harun, Siti Rafidah Yusof and Farah Wahida Suhaimi
Section 4: Pharmaceutical drug development of kratom-derived products
7. Regulation and policy regarding kratom-derived dietary supplements and direct-to-consumer sales
Robert Durkin, Oliver Grundmann and Kirsten E. Smith
8. Patentability and exclusivity of kratom based natural products
Robert Paradiso
Section 5: Concerns
9. Kratom drug-drug (and other) interactions
Robert B. Raffa and Jeanette Mathews
10. Susceptible populations
Robert B. Raffa and Jeanette Mathews
Section 6: Commentaries/Perspectives
11. Kratom purity and quality control issues: an in-depth analysis
Frank Breve
12. Kratom entrepreneurship | exploiting the commercial potential of kratom and its active alkaloids
Chad E. Beyer
13. Equity investment into kratom, mitragynine, and related products
Zachariah Mcintosh-Pearce
14. Medical marijuana as a template for understanding kratom
Soren Shade
