The multitasking molecular chaperone Hsp60 : Structure, function, and impact on health and disease

Cappello, Francesco (EDT)/ Conway de Macario, Everly (EDT)/ JL Macario, Alberto (EDT)

Academic Press Inc（2024/10発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 324 p.
• 言語 ENG
• 商品コード 9780443239960
• DDC分類 572.8

Full Description

The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies.

Molecular mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies.

Contents

The chaperone system and its diseases: Introductory overview focusing on Hsp60
Physical and biochemical properties of the molecular chaperone Hsp60
The spectrum of human Hsp60 genetic variants and associated chaperonopathies
Hsp60 in inflammation and autoimmunity
Hsp60 and carcinogenesis
Hsp60 involvement in cartilage tissue homeostasis and pathogenesis
Hsp60 and skeletal muscle diseases
Hsp60 and cardiovascular diseases
Hsp60 in physiology and pathophysiology of the respiratory system
Hsp60 and diseases of the digestive system
The chaperone system and the pathophysiology of the urogenital apparatus: Hsp60 roles
Hsp60 and nervous system development and diseases
Hsp60 and pathophysiology of the neuroendocrine system