Full Description
Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders: Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both preclinical and clinical investigations.
This book consists of the following: The program and abstracts presented at the Third International Conference in Udine, Italy, September 3-5, 2023; Parts I-V review on (I) the general properties of nitric oxide in diseases; (II) the role of nitric oxide in cancer; (III) nitric oxide and immunity; (IV) nitric oxide and aging; and (V) nitric oxide and therapeutics. In addition, part VI is an educational review on artificial intelligence and its application in diseases. These updated reviews present many examples of research investigations related to the application of novel therapeutic compounds on nitric oxide and new derivatives, as well as their significant therapeutic activities against various resistant cancers that are unresponsive to current treatments and in different inflammatory disorders.
This book is a valuable resource for cancer researchers, oncologists, graduate students, and investigators from medical and biomedical fields who want to learn more about NO and its therapeutic applications in cancer and inflammatory diseases. This book is also highly useful for both clinicians and oncologists as well as pharmaceutical companies involved in the development of new anticancer/antiinflammatory agents.
Contents
Contributors
About the editors
Preface
UDINE 2023
Objective of this volume
Highlights
I General introduction
1. Nitric oxide pathophysiology and applications in patients undergoing major cardiac surgery
Signori Davide, Mattias Carlström, Lorenzo Berra, and Rezoagli Emanuele
Abbreviations
Introduction
Pathophysiology of CSA-AKI and NO dysregulation
Renal vasoconstriction
Direct free-hemoglobin and catalytic iron injury
Ischemiaereperfusion injury
Conclusions
Conflict of interest statement
Acknowledgments
References
II Nitric oxide and cancer
2. The emerging role of dimethylarginine dimethylaminohydrolase 2 in regulating vasculogenic mimicry in cancer
Arduino A. Mangoni, Lashika Weerakoon, Vinitha N. Ragavan, Natalia Jarzebska, Roman N. Rodionov, and Sara Tommasi
Abbreviations
Introduction
Vasculogenic mimicry: Pathogenesis and clinical significance
Dimethylarginine dimethylaminohydrolase 1: Biology and role in vasculogenic mimicry
Recent developments in understanding the biological role of DDAH2 and its possible effects in vasculogenic mimicry
General considerations
Conflict of interest statement
References
III Nitric oxide reactions in the cells and models to check its biological properties
3. Decoding S-nitrosylation: Theoretical aspects and analytical approaches
Gianmarco Matrullo, Chiara Pecorari, and Giuseppe Filomeni
Abbreviations
Introduction
NO signaling
Nitric oxide in physiology and pathology
S-nitrosylation detection: Approaches and challenges
Conclusion
Conflict of interest
Acknowledgments
References
4. Preclinical models to assess the pharmacological properties of NO derivatives
Lucia Morbidelli and Valerio Ciccone
Abbreviations
From preclinical to clinical trials of drugs
Cell-based in vitro pharmacological screening and safety assessment
Ex vivo experiments
In vivo experiments to assess efficacy and safety of NO derivatives
Conclusions
Acknowledgements
References
IV
Nitric oxide and neurodegeneration
5. Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration
Jennifer Cale, Tracy D. Farr, Sebastien Serres, and Joern R. Steinert
Abbreviations
Introduction
Neurovascular oxidative and nitrergic stress
Redox stress in the vascular, neuronal, and astrocytic compartments
Therapeutic targets of NO signaling
Conclusions
Acknowledgments
References
V Nitric oxide and therapeutics
6. Role of nitric oxide in gemcitabine resistance in pancreatic cancer cells
Mariachiara Gani, Eros Di Giorgio, Raffaella Picco, Luigi E. Xodo, and Valentina Rapozzi
Abbreviations
Introduction
Acknowledgments
References
Further reading
7. Exploring the dual role of nitric oxide in glioblastoma: Therapeutic implications
Inesa Navasardyan and Benjamin Bonavida
Abbreviations
Introduction
Treatment of GBM
NO production and its biological process
Role of the INOS/NO pathway in GBM
NO-targeted therapies in GBM
Discussion
Perspectives and future directions
Acknowledgments
References
8. Nitric oxide donating systems and their potential in shaping tumor immunoregulation
Greta Varchi
Introduction
The tumor microenvironment
The enigmatic dual nature of nitric oxide in cancer
Nitric oxide donors
Nitric oxide donors and the immune system
Conclusions and future directions
References
9. Control of nitric oxide synthase 2: Role of NRF2-regulated distal enhancer
Eros Di Giorgio, Valentina Rapozzi, and Luigi E. Xodo
Abbreviations
Introduction
NOS2 structure and function
NOS2 and cancer
Transcription factors activating NOS2 expression
NRF2 controls the expression of NOS2
RF2 binds to a distal enhancer of NOS2
PDAC-spheroids formation depends on NOS2: Therapeutic implications
Concluding remarks
Conflict of interest
References
Further Reading
10. Nitric oxide in tumor biology: From stemness to metabolic reprogramming
Antonio Rodríguez-Ariza
Abbreviations
Introduction
Role of NO in the acquisition of stem characteristics and therapy resistance in breast cancer
Role of NO in the biology of intestinal cancer cells
Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer
Conclusions
Acknowledgments
References
11. Impact of nitric oxide on hemeprotein maturation and its relevance to cancer and pulmonary diseases
Chaitali Ghosh, Mamta Sumi, and Arnab Ghosh
Abbreviations
Introduction
Impact of NO on hemeprotein maturation
NO in cancer
Significance of the NO-sGC-cGMP pathway in globin maturation and relevance to cancer progression
NO in asthma and pulmonary diseases
Conclusion and future directions
Acknowledgments
References
VI Educational session
12. Using artificial intelligence to discover new cancer therapies
Apostolos Zaravinos
Index 000
