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Full Description
Fundamentals of Redox Biology is a comprehensive guide to understanding the complex roles of cellular redox systems in biological processes and human health. Exploring the regulation, physiological functions, and pathological implications of reactive oxygen species (ROS) and free radicals, this book serves as an essential resource for students and professionals in biochemistry and related fields. It delves into the fundamentals of redox signaling, the impact of antioxidants on homeostasis, and the intricate balance between oxidative stress and disease development, including conditions like cancer and neurological disorders. This foundational text is invaluable for advancing knowledge in redox biology.
In addition to providing a historical perspective on redox biology, the book examines how ROS influence epigenetic regulation and mitochondrial function, particularly in immune responses to infections. It also integrates discussions on the role of redox systems across multiple disciplines, making it relevant to cell biology, molecular biology, immunology, and beyond. With its detailed exploration of both theoretical and applied aspects, the book positions itself as a pivotal resource for understanding the mechanisms underlying redox balance and its broad applications in life sciences.
Contents
Section A: General topics
1. Free radicals and reactive species in human health and diseases: a historical perspective
2. Biochemistry of free radicals and reactive oxygen species
3. Tools and techniques for the detection and estimation of cellular ROS and other reactive species
4. Redox signaling
5. Role of ROS in genetic and epigenetic regulations
6. Cellular compartmentalization and its importance in the physiological functions of ROS
7. Antioxidants and their physiological roles in redox homeostasis
Section B: Specialized topics
8. Role of ROS in metabolism: the cancer cell paradigm
9. ROS and cardiovascular and neurological disorders
10. ROS, the immune response, and its evasion by the pathogens
11. Iron/copper homeostasis, ROS and ferroptosis
12. Role of cellular redox in organismal biology: lessons from yeast, C elegans, Zebrafish, and Drosophila
13. Role of ROS in plant development and stress responses
