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Full Description
Lipid Analysis in Biology, Health, and Disease bridges the gap between discovery science and clinical lipidology, empowering both scientific and medical communities to apply lipid analysis and understanding in new research, as well as diagnosis and management of diseases. Here, international experts in the field begin with the basic biology of the lipids, followed by methods and technology for study, and lipids in lab medicine and epidemiology. This book uniquely combines biology and analysis to drive healthcare advances, with a diverse range of technologies and analytic methods considered.
Basic lipid biology chapters discuss membrane expansion, lysosomal positioning, mitochondrial biogenesis, lipid-protein interactions, molecular dynamics, cholesterol transport, immune activation and inflammation, lipid droplets, and gender differences in lipid metabolism. Each disease chapter incorporates basic lipid epidemiology, risk factors, and genetic associations.
Contents
Section 1: Lipids in Different Aspects of Biology:
1. Membrane Expansion
2. Contribution of lipids towards membrane curvature
3. Lipid-Protein Interactions and Molecular Dynamics Simulation
4. Lipid Droplets in Biology
5. Lysosome and lipid metabolism
6. Mitochondrial and Cardiolipin Biology
7. Cholesterol transport by various lipoproteins
8. Lipids mediators in viral infection and immunity
9. Gender Differences in Lipid Metabolism
Section 2: Analytical Technologies
10. Analyses of different aspects of lipids: General methods
11. Current LC-MS/MS methods in lipidomics
12. Gas chromatography-mass spectrometry (GC-MS) analyses of lipids
13. Rapid and unbiased screening of serum lipid ratios using AP MALDI-HRMS
14. Nuclear magnetic resonance (NMR) methods for Lipid analysis
15. The statistical analysis of 'Omics datasets: challenges, pitfalls, and tips
16. Differences in lipidomic analysis using different bioinformatics software
17. Metabolomics Tools for the Analysis of Phospholipids as Potential Markers to Decipher the Molecular Mechanisms Behind Diseases
18. Lipid Imaging: Microscopy-Based Techniques for Lipid Membrane Characterization
Section 3: Lipids in Lab and Investigational Medicine
19. Multi-omics biomarkers of health and disease
20. The Multifactorial Pathobiology of Lipidic Quorum Signaling Molecules of Pseudomonas aeruginosa
21. Targeting Fatty Acid Transport in Dietary Lipid Absorption: A Therapeutic Approach for Metabolic Disorders.
22. Lipoprotein metabolism and female fertility
23. The Role of Maternal Omega-3 Supplementation in Shaping Offspring Skeletal Health
24. Oxidized lipids and age-related macular degeneration
25. Lipidomics of Human Aqueous Humor
26. Drug Delivery Systems Involving Lipids
Section 4: Lipids in Clinical Medicine
27. Cardiovascular diseases and cholesterol
28. Cholesterol and Spingolipids in Alzheimer's disease
29. Cardiac lipotoxicity in diabetes and obesity
30. Lipid metabolism in type 1 diabetes initiation and progression to vascular disease
31. Role of the Gut Microbiome in Lipid Metabolism and type 1 diabetes
32. Elevated LDL levels and lung cancer
33. Pathophysiology and Clinical Medicine of Dyslipidemia after Spinal Cord Injury
34. Targeting transcription control of lipid biogenesis to tune intraocular pressure
35. Inflammatory Bowel Disease
36. Atherosclerosis and Inflammation
37. Lipidomics in Skeletal Muscle: Unveiling the Roles of Lipid Mediators in Muscle Biology
38. Lipidomics in Skeletal Muscle: Unveiling the Roles of Lipid Mediators in Muscle Pathophysiology
39. Lipidomics in Bone: Unveiling the Roles of Lipid Mediators in Bone Biology and Pathophysiology
40. Associations of Lipids With Diseases in Large Cohort Studies and Randomized Trials
