Full Description
Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiology and pathology. It discusses the role DNA methylation plays in regulating genomic functions, which in turn guide brain function. The book explores the epigenetic role in cell type differentiation, epigenetic processes in memory, learning, and neuronal functioning, the role of DNA methylation and other epigenetic mechanisms in sleep, feeding and metabolic control, sex, temperature regulation, and cardiovascular and blood pressure regulation. It further explores the role of epigenetic processes in neuropsychiatry disorders, neurological disease and behavioral disorders, as well as epigenetic diagnostics and therapeutics.
Contents
1. Introduction. Epigenetic mechanisms in brain function.
2. Evolution of epigenetic landscapes during pre and postnatal brain development and aging.
3. The role of DNA methylation and stepwise oxidation of 5 methylcytosine in epigenetic regulation of gene expression in the brain.
4. Learning and memory.
5. Stress and the HPA axis
6. Metabolic homeostasis
7. Puberty and sexual behavior
8. Body Temperature and thermal regulation
9. The role of epigenetic mechanism in the neuroimmune axis
10. The impact of genetic alterations in epigenetic proteins on brain disorders.
11. Epigenetic processes in neurodevelopmental disorders (RETT syndrome, Autism)
12. Linking early adversity epigenetics and neuropsychiatric disorders (psychosis)
13. Epigenetic processes in substance abuse, and behavioral addictions
14. Epigenetic processes in neurological diseases Alzheimer, Parkinson disease, Parkinson, ALS
15. Epigenetic mechanisms in chronic pain
16. Early life adversity trauma and PTSD linked by epigenetic mechanisms
17. Epigenetic mechanisms in brain aging, cognitive decline and dementia
18. Methodological challenges in epigenome wide associations with neuropsychiatry and behavioraldisorders
19. Animal models with construct validity for studying epigenetic processes in neurobehavior
20. Using epigenetic editing and to examine the role of site specific DNA methylation and oxidationalterations in neuroepigenetics.
21. Methods for dissecting cell neuron/glia/astrocyte specific patterns of methylationIPSC stem cells derived neuronal precursor cells to model in vitro the role of DNA methylation in the nervous system and brain disorders
