Full Description
Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity.
Divided into two parts, the foundational aspects of this book cover the mechanism of toxicity in a detailed manner beginning with the history of acetaminophen to newly explored areas of genetics, proteomics, and metabolomics. The second half goes on to discuss clinical practices and examine where further research and therapeutic approaches may be headed. This part answers key questions about whom to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments.
With contributions from experts in the field, this book is a thorough, well-researched, and valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with acetaminophen toxicity.
Contents
PART I: Foundational Aspects
1. History of Acetaminophen
2. Intracellular Signaling Mechanisms of Cell Death.
3. Hepatic MAP kinase signaling pathways in APAP-induced cell death
4. Adaptive Mechanisms modulating APAP-induced Cell Death
5. Mode of Cell Death
6. Inflammation
7. Hepatic Regeneration
8. Translation of Acetaminophen Hepatotoxicity Mechanisms from Models to Humans
9. Renal Toxicity
10. Genomics, Proteomics and Metabolomics
Part II: Clinical and Therapeutic
11. Pharmacokinetics and pharmacodynamics - the absorption, distribution, metabolism and excretion of acetaminophen orally and intravenously
12. Minimally Invasive Clinical Biomarkers for use in Acetaminophen Hepatotoxicity
13. Adducts
14. The Rumack-Matthew Nomogram: Development, evolution, and use
15. Pathophysiology of Acetaminophen Overdose
16. Kings College Criteria and Liver Transplantation
17. Sustained-Release Acetaminophen
18. Acetaminophen, Ethanol and other Co-Ingestions
19. N-Acetylcysteine (NAC)
20. Fomepizole
21. Pre-Hospital, Poison Center and Initial Hospital Care of Overdose and Potential Overdosed Patients
22. Epidemiology NPDS (Poison Center Data) CDC and Other Databases
23. Acetaminophen safety in chronic liver diseases
