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Full Description
Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds will be of great interest to undergraduate and graduate students, scientists, researchers, and engineers who work on the microbial production of plant-derived bioactive compounds. As many plant-derived bioactive compounds are the foundation of effective drugs to cure diseases, it's important to understand the limits of their applications in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast.
This book summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing the content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks.
Contents
1. Mining bioparts for the biosynthesis of plant-derived bioactive compounds via omics and bioinformatics technologies
Zheyong Xue, Yanlin Li, Xue Yin, Yanhong Guo and Jia Liu
2. DNA assembly techniques for the reconstitution of plant natural product biosynthetic pathways in Saccharomyces cerevisiae
Jiazhang Lian
3. The application of gene-editing technologies in the biosynthesis of plant-derived bioactive compounds
Xin Sun, Meng Li, Yiting Mei and Meirong Jia
4. Pathway engineering of plant-derived bioactive compounds in microbes
Yun Liu, Dadeng Zhang, Tongjian Yang, Ruidong Chen and Xiaozhou Luo
5. Construction and application of a genome-scale metabolic network model for plants
Jinyi Qian and Chao Ye
6. Metabolic design—build—test—learn cycle used for the biosynthesis of plant-derived bioactive compounds
Yongkun Lv and Weigao Wang
7. Microbial cell factories for the synthesis of plant-derived bioactive compounds: metabolic flux dynamic regulation
Yameng Xu, Xiaoyang Ge, Ximan Hu, Xinrui Chen, Zhitian Zhang and Yonglin Zhang
8. Yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids
Yapeng Zhang and Chun Li
9. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids
Qi Guo and Tian-Qiong Shi
10. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive flavonoids
Lin Hu, Liuheng Huang, Huihui Qiu, Fenghui Zhang, W.H. Nishani De Soyza, Ning He and Mingfeng Cao
11. Non-yeast fungal cell factories for the biosynthesis of plant-derived bioactive compounds
Gen Zou
12. Fine-tuning and dynamic control of microbial cell factories for the biosynthesis of plant-derived bioactive compounds
Lidan Ye
13. Biofoundries for plant-derived bioactive compounds
Lihang Xie
14. Engineering biology fundamental for plant-derived bioactive compounds: challenges and prospects
Ruibing Chen and Lei Zhang
15. Reprogramming microbial cell factories to overproduce plant natural products through directed genome evolution
Zhihui Shi and Guokun Wang
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