Full Description
Clinical Cancer Genomic Medicine covers all major aspects of genetics and genomics in cancer development, diagnosis, and management, and their use in the clinical setting. The book explores not only the genetic basis of cancer, but also the role genomics plays in understanding the molecular basis of disease and how it can aid in diagnosis and treatment. Sections discuss the basics of oncogenomic and emerging technologies and specific cancer types, such as breast, gastrointestinal, ocular, skin, and pediatric. The book also includes knowledge on diagnostic cancer genomic techniques, surgical approaches, and ethical, legal, and social implications.
This is a valuable resource for oncologists, clinicians, researchers, healthcare workers, and members of the biomedical field who need to understand more about the benefits of genetics and genomics for cancer and their applications in the clinical setting.
Contents
Section I: Fundamentals of Cancer genetics and genomics
1. The human genome- organisation & function
2. Introduction to cancer genetics
3. Oncogenes and tumour suppressor genes
4. Cancer epigenomics
5. Cancer and the microbiome- the Oncobiome
6. Cancer immunogenomics
7. Cancer pharmacogenomics
8. Genomic Technologies for Tumour Profiling
9. New emerging technologies- The liquid biopsy
10. Gene and genome editing
11. Bioinformatics for Cancer Genome Analysis
Section II: Clinical cancer genetics and genomics
12. Classification and epidemiology of the genetic and inherited cancer - hereditary cancer family syndromes
13. Breast and ovarian cancer including endometrial cancer
14. Gastrointestinal malignancies - oesophagus, colo-rectal, hepato-biliary and pancreatic
15. Central nervous system tumours
16. Neoplasia of endocrine system (solitary and multiple)
17. Ocular tumours - retinoblastoma
18. Hematological cancer and lympho-reticular malignancy
19. Oro-pharyngeal and lung cancers
20. Malignant melanoma and related skin neoplasia
21. Childhood tumours and paediatric malignant neoplasia disorders
22. Malformation syndromes with neoplasia
Section III: Clinical cancer genomic medicine
23. Integration of cancer genomics in clinical medicine
24. Cancer genetic counselling
25. Diagnostic cancer genomic laboratory - organization & function / cancer database
26. Targeted therapy and screening in cancer genomic / precision medicine
27. Surgical approaches in clinical cancer genetics and genomics
28. Ethical, legal and social implications of cancer genomic testing
29. The future of cancer in the context of the genomics era
