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Full Description
Handbook of Endocannabinoid Function in the Central Nervous System, a new release in the Handbook of Behavioral Neuroscience series, offers a comprehensive, interdisciplinary approach to understanding the role of the endocannabinoid system in functions of the central nervous system. This new volume brings together the most influential and internally recognized experts in the field to provide a detailed overview of the physiological and pathophysiological roles of endocannabinoids in CNS activity. It covers the history, functional anatomy, and neurophysiology of the endocannabinoid system, moving on to assess endocannabinoid roles across human lifespans, and in behavioral control.
Final sections of the book explore the use of endocannabinoids in psychiatric and neurological disorders. This is a vital resource for neuroscientists, neuropharmacologists, and neuropathologists, as well as any researcher seeking detailed discussions of brain endocannabinoid functions.
Contents
Section I - History of the endocannabinoid system
1. An insider view of the discovery of the endocannabinoid research
2. The endocannabinoid system: present, future
3. Medical chemistry of the eCB system
Section II - Functional anatomy of the endocannabinoid system
4. The endocannabinoid signalosome
5. Endocannabinoid biosynthesis, degradation, and transport
6. Structure and distribution of endocannabinoids' receptors
7. Endocannabinoid in glial cells
8. Endocannabinoid in non-neuronal cells of the CNS
9. Endocannabinoid - lipid interactions
10. Endocannabinoid and mitochondria
11. Sexual differences in the endocannabinoid system
Section III - The neurophysiology of the endocannabinoid system
12. Cellular effects of endocannabinoid in the CNS
13. Endocannabinoids control of excitability: from neuron to networks
14. Endocannabinoids control of synaptic transmission: from neuron to networks
15. Endocannabinoids - pain modulation
16. Endocannabinoids regulation of striatal functions
17. Endocannabinoids regulation of hippocampal functions
18. Endocannabinoids regulation of the mesolimbic system
19. Endocannabinoids regulation of cortical functions
20. Endocannabinoids regulation of spino-cerebellar functions
21. Peripheral and central endocannabinoids in the regulation of metabolism
Section IV - Endocannabinoids in development and lifetime
22. Roles of eCB in the fetal brain and early postnatal development
23. Roles of eCB in adolescence and sensitive periods
24. Roles of eCB in aging
25. Epigenetic control of eCB
26. Perinatal cannabinoid exposure
Section V - Endocannabinoids and behavioral control
27. Endocannabinoids and sensory processing
28. Endocannabinoids in motor control
29. Role of the eCB system in appetite and eating behavior
30. Endocannabinoids and the neurobiology of emotional states
31. Endocannabinoids and social behavior
32. The role of endocannabinoids in impulsivity, compulsivity, and decision-making
33. Endocannabinoids in learning and memory
34. Endocannabinoids in cognition
Section VI - Endocannabinoids in psychiatric disorders
35. Anxiety and depression
36. Endocannabinoids and schizophrenia
37. Endocannabinoid neurobiology in cannabis use disorder
38. The role of endocannabinoids in alcohol use and abuse
39. The role of endocannabinoids in psychostimulant addiction
40. The role of endocannabinoids in opioid abuse and addiction
41. Endocannabinoids in eating disorders
42. Endocannabinoids in autism spectrum disorder
43. Endocannabinoids in mental disorders
44. Endocannabinoids in OCD and Tourette's
Section VII - Endocannabinoids in neurological disorders
45. Endocannabinoids in Parkinson's disease and neurodegenerative diseases
46. Endocannabinoids in seizures and epilepsy
47. Endocannabinoids and stroke
48. Endocannabinoids and Alzheimer's
49. Endocannabinoids and multiple sclerosis
50. Endocannabinoids and brain cancer
