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Full Description
T Cell Metabolism and Cancer Immunotherapy delves into the intricate regulation of T-cell immunity and tolerance. As research advances in cell-based therapies, the potential of engineered immune cells to treat cancers and other diseases is becoming increasingly evident due to their powerful capabilities. Additionally, the book offers valuable insights into developing and optimizing strategies for bacterium-based immunotherapies.
Despite great advancement in immunotherapy such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy. By determining the role and importance of T cell metabolism in the regulation of T lymphocytes that are related to the development and managements of aberrant immunity, T Cell Metabolism and Cancer Immunotherapy designs and develops novel and more effective strategies for improving regimens for patients with aberrant immunity.
Within ten chapters the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy.
Contents
1. Modulating T cell metabolism to improve T cell therapy
2. Links between the DNA damage response and immune response in cancer
3. Improving adoptive T cell therapy by positive conversion of negative signaling
4. TGF-β in tumor microenvironment, metabolism, and immunotherapy
5. Targeting Immunometabolism to Improve Cancer Therapies
6. TCR-T Cells for Cancer Immunotherapy
7. The Combination of Local Treatment and Immunotherapy
8. T cell metabolism and cancer immunotherapy
9. Exploring the Interplay of Kinases and Transcription Factors in Immunometabolism
10. Targeting Engineered Bacteria to Improve Cancer Immunotherapy
11. Salmonella: A Bacterial Warrior in Cancer Immunotherapy
12. Oncolytic Virus for Cancer Immunotherapy
13. Advances in Immunotherapy for Colorectal Cancer
