Full Description
This core textbook discusses the presentation and pathophysiology, differential diagnosis, management, and prognosis for a comprehensive range of pediatric rheumatic conditions. Global leaders in the field provide evidence-based guidance highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies the investigation, recognition, and management of rheumatic diseases in childhood and adolescence.
Addresses the full spectrum of rheumatic diseases, from typical juvenile idiopathic arthritis to rare and newly recognized syndromes, providing practical guidance on diagnosis, outcome measurement, and management-including both pharmacologic and multidisciplinary strategies
Covers state-of-the-art advances in pediatric rheumatology, including genomic and multi-omics approaches, the latest targeted therapies, modern imaging, and evolving concepts in autoinflammation and immune deficiency
Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible, and provides updates of laboratory investigations, imaging techniques, physical and occupational therapy, approach to chronic musculoskeletal pain syndromes, and much more
Features reviews of the complex symptoms, signs, and laboratory abnormalities that characterize these disorders
Shares the knowledge and expertise of two new editors, Drs. Jonathan Akikusa and Hermine Brunner, and 38 new contributing authors who are international leaders in the field of pediatric rheumatology
An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud
Contents
Section 1. Introduction
1. Evolution of Pediatric Rheumatology
Section 2: Basic Concepts
2. Structure and Function
3. Innate Immunity
4. Adaptive Immunity
5. Multi-omics Approaches to Rheumatic Disease
6. Genetics and Pediatric Rheumatic Diseases
Section 3: Clinical Research in Pediatric Rheumatology
7. Understanding Clinical Investigations
8. Clinical Outcome Measures in Pediatric Rheumatic Diseases
Section 4: Clinical Investigations in Pediatric Rheumatology
9. Laboratory Investigations
10. Imaging in Pediatric Rheumatic Diseases
Section 5: Management of Rheumatic Diseases in Children
11. Principles in the Management of Patients with Rheumatic Diseases
12. Therapeutics: Nonbiologics
13. Therapeutics: Biologics and Targeted Small Molecules
14. Physical and Occupational Therapy
15. The Assessment and Management of Osteoporosis in Childhood
Section 6: Juvenile Idiopathic Arthritis and Related Conditions
16. Juvenile Idiopathic Arthritis: Classification and Basic Concepts
17. Systemic Juvenile Idiopathic Arthritis
18. Polyarticular Juvenile Idiopathic Arthritis
19. Oligoarticular Juvenile Idiopathic Arthritis
20. Enthesitis-Related Juvenile Idiopathic Arthritis
21. Psoriatic Juvenile Idiopathic Arthritis
22. Uveitis in Juvenile Idiopathic Arthritis
Section 7 Arthritis Related to Infection
23. Acute Rheumatic Fever and Post-Streptococcal Arthritis
24. Reactive Arthritis
25. Lyme Disease
26. Infectious Arthritis and Osteomyelitis
Section 8: Autoimmune and Inflammatory Connective Tissue Disorders and Related Syndromes
27. Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease
28. Neonatal Lupus Erythematosus
29. Antiphospholipid Syndrome
30. Juvenile Dermatomyositis and Other Inflammatory Muscle Diseases
31. Juvenile Systemic Sclerosis
32. Localized Scleroderma and Eosinophilic Fasciitis
33. Sjögren Disease and Immunoglobulin-G4 Related Disease
34. Raynaud Phenomena and Vasomotor Syndromes
35. Inflammatory Central Nervous System Disorders
Section 9: Vasculitis
36. Vasculitis and Its Classification
37. Takayasu Arteritis
38. Polyarteritis Nodosa
39. Kawasaki Disease
40. Antineutrophil Cytoplasmic Antibody Associated Vasculitis
41. Immune Complex Small-Vessel Vasculitis: IgA Vasculitis and Hypersensitivity Vasculitis
42. Behcet Syndrome and its Mimics
43. Central Nervous System Vasculitis
44. Other Vasculitides
Section 10:Immune System Dysfunction, Autoinflammation and Immune Deficiency
45. Periodic Fever Syndromes and Other Inherited Autoinflammatory Diseases
46. Autoinflammatory Bone Diseases
47. Blau Syndrome, Sarcoidosis and Related Systemic Granulomatous Diseases
48. Macrophage Activation Syndrome
49. Inborn Errors of Immunity and Rheumatic Diseases
Section 11. Musculoskeletal Manifestations of Systemic Disorders
50. Malignancies and Non-malignant Musculoskeletal Conditions That May Mimic Rheumatic Disease
51. Musculoskeletal Manifestations of Inflammatory Bowel Disease
52. Musculoskeletal Manifestations of Systemic Disease
Section 12. Non-Inflammatory Musculoskeletal Conditions and Pain Syndromes
53. Primary Disorders of Connective Tissue
54. Localized Musculoskeletal Pain
55. Primary and Secondary Chronic Musculoskeletal Pain Syndromes
